ISSN:
1432-1106
Keywords:
Hyperphenylalanaemia
;
Tyrosine
;
Blood-brain exchange
;
Cerebral protein synthesis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary An account is given of an experimental design and a computing procedure for in vivo measurement of the blood-tissue exchange of amino acids and the metabolic rate of tissue proteins with radioactively labelled amino acids. The method was used for evaluation of the exchange rates of tyrosine between the plasma and the brain and between the free and protein-bound tyrosine compartments in the brain of adult rats in experimental hyperphenylalanaemia and hypertyrosinaemia. Hyperphenylalanaemia inhibited the exchange of tyrosine between plasma and brain. In both hyperphenylalanaemic and hypertyrosinaemic rats the rate of synthesis of the cerebral proteins fell. Alterations in the intracerebral pool of free amino acids produced by excessive loading with phenylalanine or tyrosine are suggested as the cause of the impairment of cerebral protein synthesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00234910
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