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  • 1
    ISSN: 1432-0584
    Keywords: Non-Hodgkin's lymphomas ; Chemotherapy ; Consolidation therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Twenty four patients with high grade malignant NHL (stage II 8, stage III 4, stage IV 12 patients respectively) were treated with a response-oriented regimen: Treatment was initiated according to the CHOP-protocol. Patients achieving at least a partial remission after 2 and a complete remission (CR) after 4 cycles were continued on CHOP to a total of 9 cycles. Patients not meeting these criteria were switched to a combination of Etoposide, Ifosfamide, Methotrexate, and Bleomycin (VIM-Bleo). With CHOP treatment, 16 patients (67%) achieved a CR. Of the remaining 8, 7 were treated with VIM-Bleo; 5 of these entered CR for a overall CR rate of 21/24 (88%). With a median follow up of 28 months 7 patients relapsed: 6 relapses occurred in patients with a rapid initial response and treated only with CHOP. We conclude, that there is a significant risk of relapse even in patients readily responding to CHOP and that consolidation therapy with a non cross-resistant regimen may improve results in these patients.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 653-655 
    ISSN: 1435-2451
    Keywords: Cervical biopsy ; Neurological complications ; Suitable anaesthesia ; Probeexcision im Halsbereich ; Neurologische Komplikationen ; Geeignete Anaesthesie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 433 Patienten mit Probeexcision im Bereich des Halses fanden sich neben Lymphadenitiden in erster Linie hämatologische Malignome und Metastasen maligner Tumoren. In 4,8 % traten behandlungsbedürftige Komplikationen auf, zum einen Wundheilungsstörungen (Hämatome, Entzündungen), zum zweiten neurologische Komplikationen des Nervus accessorius. Bei 4 Patienten bildeten sich diese vollständig zurück, einmal blieb eine Parese des Musculus deltoideus bestehen. Die Analyse des Krankengutes läßt erkennen, daß vor allem ungeeignete Narkoseverfahren (Lokalanaesthesie) bei in der Tiefe gelegenen, schlecht abgrenzbaren Tumoren zu Komplikationen geführt hatten.
    Notes: Summary In 433 cervical biopsies lymphadenitis, metastases of malignant tumors and of the haematologic system could be found first of all. In 4.8 % complications needed a further treatment, firstly trouble in wound healing (haematoma, inflammation), secondly neurological complications of the accessorial nerve. These complications receded in 4 patients completely, in one patient a paralysis of the deltoid muscle continued. The analysis of our patients suggested that unsuitable anaesthesia (local anaesthesia) for deeper-seated, badly demarked tumors is responsible for most of the complications.
    Type of Medium: Electronic Resource
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