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Identification of alpha1-adrenoceptor subtypes in the human prostatic urethra (1997)

Taniguchi, N. ; Ukai, Y. ; Tanaka, T. ; [et al.]

Springer

Naunyn-Schmiedeberg's archives of pharmacology 355 (1997), S. 412-416

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ISSN: 1432-1912

Keywords: Key wordsα1-adrenoceptor subtypes ; Urethra ; Cloned receptor ; NS-49 ; Binding assay ; Correlation

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract To identify the α1-adrenoceptor subtypes in the human prostatic urethra, we compared the potencies of various α1-adrenoceptor agonists and antagonists in inhibiting [3H]tamsulosin binding to human prostatic urethral membranes with their potencies in inhibiting the binding of (+)-β-([125I]iodo-4-hydroxyphenyl)ethylaminomethyl-tetralone ([125I]HEAT) to cloned human α1a, α1b and α1d subtypes. The α1A-selective antagonists 5-methylurapidil and (+)niguldipine showed higher affinities for both cloned α1a and urethral α1-adrenoceptors than for cloned α1b- and α1d-adrenoceptors. NS-49, (R)-3′-(2-amino-1-hydroxyethyl)-4′-fluoromethanesulfonanilide hydrochloride, recently characterized as an α1A-selective agonist, also showed high affinity for the cloned α1a subtype and urethral α1-adrenoceptors. Prazosin showed lower affinity for α1-adrenoceptors in the human prostatic urethra than for any of the three cloned α1-adrenoceptors. Comparison of the affinities of α1-adrenoceptor agonists and antagonists for human prostatic urethral α1-adrenoceptors to their affinities for the three cloned α1 subtypes indicated a close correlation between the affinities for human urethral α1 and the cloned α1a-adrenoceptors. However, prazosin did not conform to this pattern. These findings suggest that the predominant α1-adrenoceptor in the human urethra is the α1A subtype, and that an α1L subtype which has been characterised by its low affinity for prazosin, may also be present.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/PL00004962

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Selective adsorption of bilirubin by macroporous poly(glycidyl methacrylate-co-divinylbenzene) beads (1996)

Kuroda, H. ; Tanaka, T. ; Osawa, Z.

Weinheim : Wiley-Blackwell

Angewandte Makromolekulare Chemie 237 (1996), S. 143-161

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ISSN: 0003-3146

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Description / Table of Contents: Makroporöse Glycidylmethacrylat(GMA)-Divinylbenzol(DVB)-Copolymerstränge wurden synthetisiert, und die Adsorption von Bilirubin, Albumin und anderen Serumkomponenten wurde untersucht. Die aus DVB/GMA im Gewichtsverhältnis 75/25 aufgebauten Stränge bieten eine hervorragende Bilirubin-Adsorptionsfähigkeit. Wenn die Oberfläche der Stränge vorher mit Albumin beschichtet wurde, wird selektive Adsorption von Bilirubin erzielt, und die Adsorption von Albumin im Serum wird unterdrückt. Außerdem wurde durch Vernetzung des beschichteten Albumins mit Glutaraldehyd die hervorragende Bilirubin-Adsorptionsfähigkeit bewahrt und eine zusätzliche Adsorption von Albumin aus dem Serum erzielt.

Notes: Macroporous glycidyl methacrylate (GMA)-divinylbenzene (DVB) copolymer beads have been synthesized and the adsorption of bilirubin, albumin and other serum components were studied. The beads composed of DVB/GMA in the weight ratio of 75/25 provide an excellent bilirubin adsorption ability. When the surface of the beads was previously coated with albumin, discriminating adsorption of the bilirubin in the serum was attained and the adsorption of albumin was depressed. In addition, when the coated albumin was crosslinked with glutaraldehyde, the excellent bilirubin adsorption ability was maintained, however, an adsorption of albumin from the serum occurred.

Additional Material: 12 Ill.