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  • Chemistry  (11)
  • Spinal cord  (4)
  • Amyotrophic lateral sclerosis  (3)
  • 1
    Digitale Medien
    Digitale Medien
    Morphological analysis of the cervical spinal canal, dural tube and spinal cord in normal individuals using CT myelography (1996)
    Springer
    Neuroradiology 38 (1996), S. 148-151 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Key words Developmental spinal canal stenosis ; Myelopathy ; CT myelography ; Spinal cord
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract To verify the conventional concept of “developmental stenosis of the cervical spinal canal”, we performed a morphological analysis of the relations of the cervical spinal canal, dural tube and spinal cord in normal individuals. The sagittal diameter, area and circularity of the three structures, and the dispersion of each parameter, were examined on axial sections of CT myelograms of 36 normal subjects. The spinal canal was narrowest at C4, followed by C5, while the spinal cord was largest at C4/5. The area and circularity of the cervical spinal cord were not significantly correlated with any parameter of the spinal canal nor with the sagittal diameter and area of the dural tube at any level examined, and the spinal cord showed less individual variation than the bony canal. Compression of the spinal cord might be expected whenever the sagittal diameter of the spinal canal is below the lower limit of normal, that is about 12 mm on plain radiographs. Thus, we concluded that the concept of “developmental stenosis of the cervical spinal canal” was reasonable and acceptable.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00604802
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  • 2
    Digitale Medien
    Digitale Medien
    Morphological analysis of the cervical spinal canal, dural tube and spinal cord in normal individuals using CT myelography (1996)
    Springer
    Neuroradiology 38 (1996), S. 148-151 
    Details
    ISSN: 1432-1920
    Schlagwort(e): Developmental spinal canal stenosis ; Myelopathy ; CT myelography ; Spinal cord
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract To verify the conventional concept of “developmental stenosis of the cervical spinal canal”, we performed a morphological analysis of the relations of the cervical spinal canal, dural tube and spinal cord in normal individuals. The sagittal diameter, area and circularity of the three structures, and the dispersion of each parameter, were examined on axial sections of CT myelograms of 36 normal subjects. The spinal canal was narrowest at C4, followed by C5, while the spinal cord was largest at C4/5. The area and circularity of the cervical spinal cord were not significantly correlated with any parameter of the spinal canal nor with the sagittal diameter and area of the dural tube at any level examined, and the spinal cord showed less individual variation than the bony canal. Compression of the spinal cord might be expected whenever the sagittal diameter of the spinal canal is below the lower limit of normal, that is about 12 mm on plain radiographs. Thus, we concluded that the concept of “developmental stenosis of the cervical spinal canal” was reasonable and acceptable.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00604802
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  • 3
    Digitale Medien
    Digitale Medien
    A unique pattern of astrocytosis in the primary motor area in amyotrophic lateral sclerosis (1991)
    Springer
    Acta neuropathologica 82 (1991), S. 456-461 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Amyotrophic lateral sclerosis ; Primary motor area ; Betz cell ; Glial fibrillary acidic protein ; Immunocytochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary We examined the primary motor area (PMA, Brodmann area 4) from 23 cases of adult-onset sporadic amyotrophic lateral sclerosis (ALS) with immunocytochemistry using anti-glial fibrillary acidic protein antibody. There was astrocytosis in the middle of the pyramidal cell layer in all cases except for one that did not present any upper motor neuron signs clinically. The astrocytosis was characterized by multiple clusters of astrocytes, some of which showed a close association with macrophages. In about a half of the cases, these multiple clusters of astrocytes became confluent and presented as a laminar astrocytosis in the middle of the pyramidal cell layer. Our studies demonstrate a unique pattern of astrocytosis in the PMA in ALS. This pattern of astrocytosis may be useful not only for diagnostic purposes, but also for a better understanding of the pathological process involving the PMA in ALS.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00293379
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  • 4
    Digitale Medien
    Digitale Medien
    Selective sparing of Betz cells in primary motor area in hypoxic-ischemic encephalopathy (1990)
    Springer
    Acta neuropathologica 80 (1990), S. 560-562 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Betz cells ; Primary motor area ; Hypoxicischemic encephalopathy ; Amyotrophic lateral sclerosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Two cases of postoperative hypoxic-ischemic encephalopathy are described in which Betz cells of the primary motor area were selectively spared. In one patient the hypoxic-ischemic encephalopathy led to a vegetative state and in the other patient to a spastic quadriparesis and cortical blindness. In contrast to the relative sparing of Betz cells, Purkinje cells of the cerebellar cortex were totally destroyed. These two cases suggest that Betz cells are relatively resistant to hypoxic-ischemic insult under certain conditions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00294620
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  • 5
    Digitale Medien
    Digitale Medien
    Immunocytochemical and ultrastructural studies of upper motor neurons in amyotrophic lateral sclerosis (1992)
    Springer
    Acta neuropathologica 83 (1992), S. 518-524 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Amyotrophic lateral sclerosis ; Upper motor neurons ; Ultrastructure ; Neurofilament ; Ubiquitin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The pathological alterations in upper motor neurons were investigated in 27 cases of adult-onset sporadic amyotrophic lateral sclerosis (ALS). No signficant cytoskeletal alterations were found in the Betz cells of any of the cases except one, although cytoskeletal pathology was consistently present in lower motor neurons. The one case had severe circumscribed atrophy of the precentral gyrus and, microscopically, had argentophilic intracytoplasmic inclusions in Betz cells and other pyramidal neurons in the primary motor area as eell as in the lower motor neurons. Immunocytochemically these inclusions contained the epitope of phosphorylated neurofilament and ubiquitin and ultrastructurally consisted of granule-associated filaments with neurofilaments. This is the first demonstration of alterations of cytoskeleton and ubiquitination in the giant cells of Betz, an established subset of upper motor neurons in ALS. Thus, although uncommon, cytoskeletal changes can be found in upper motor neurons in some ALS cases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00310029
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  • 6
    Digitale Medien
    Digitale Medien
    Spinal epidermoid cyst in the mouse (1981)
    Springer
    Acta neuropathologica 53 (1981), S. 81-85 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Epidermoid cyst ; Epidermal differentiation ; Spinal cord ; Mouse ; Ultrastructural study
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Ultrastructural features of epidermoid cysts in the spinal leptomeninges were studied in two strains of mouse. Although the cysts were lined by stratified squamous epithelium, the normal sequence of epidermal differentiation in this epithelium was not observed in that the basal cell layer was absent in certain areas. The morphological features and genesis of this phenomenon are briefly discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00697188
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  • 7
    Digitale Medien
    Digitale Medien
    Demyelination in the spinal cord of murine globoid cell leukodystrophy (the twitcher mouse) (1984)
    Springer
    Acta neuropathologica 62 (1984), S. 298-308 
    Details
    ISSN: 1432-0533
    Schlagwort(e): Globoid cell leukodystrophy ; Twitcher mouse ; Demyelination ; Spinal cord
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Chronologic events of demyelination were investigated in the spinal cord of the twicher mouse, an authentic murine model of human globoid cell leukodystrophy (GLD) from 5 to 45 days postnatal. There was very little evidence of myelin degeneration before day 25 although clustered or scattered globoid cells were already noted in the dorsal columns and intramedullary portion of the ventral roots. Globoid cells contained typical cytoplasmic inclusions and in those which were found adjacent to degenerating myelin and naked axons, myelin debris were conspicuous in their cytoplasm. Vesiculation of myelin and a feature of globoid cells stripping myelin lamellae were noted in the area of demyelination. Myelin and oligodendroglial degeneration became pronounced throughout the spinal white matter after day 40 but globoid cells tended to be more concentrated in the dorsal columns. Our observations suggest that the emergence of globoid cells in GLD is in response to the changes in biochemical environment (i.e., excessive presence of galactosylceramide in the tissue?), and these cells appear to have a role as phagocytic cells in removing myelin lamellae.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00687612
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  • 8
    Digitale Medien
    Digitale Medien
    Highly wettable films plasma-polymerized from ethylene oxide (1987)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part A: Polymer Chemistry 25 (1987), S. 1633-1639 
    Details
    ISSN: 0887-624X
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Highly wettable films were prepared by plasma-polymerization from ethylene oxide. The surface energy of the formed films is 65.6 dyn/cm, and the contact-angle of water on the films is 12 degrees. The formation of highly wettable films is limited to the plasma-polymerization conducted at low W/FM values of below 200 MJ/kg. Analyses by infrared spectroscopy and ESCA show that the formed films contain much oxygen residues such as C—O, C—O, and C(O)—O— groups. Such polar groups would contribute high wettability of the plasma-films from ethylene oxide.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/pola.1987.080250616
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  • 9
    Digitale Medien
    Digitale Medien
    A production of monoclonal antibodies by a simple electrofusion technique induced by ac pulses (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 37 (1991), S. 790-794 
    Details
    ISSN: 0006-3592
    Schlagwort(e): Electrofusion ; AC pulses ; Monoclonal antibodies ; Chemistry ; Biochemistry and Biotechnology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: A simple and effective technique of electrofusion of the mouse myeloma cells and lymphocytes induced by AC pulses was investigated. Instead of pearl chain formation, we used a mild centrifugation of high-density cell suspensions to enhance the cell-cell contacts. The optimal frequency of the AC field used for cell fusion was 10 kHz. We confirmed the production of monoclonal antibodies against human serum albumin (HSA) by the hybridoma obtained by this method. Under the conditions used in the present work, the efficiency of hybridoma formation is several times higher than those obtained by the chemical method using polyethylene glycol (PEG). Hybridoma colonies were detected in as high as 95% of the wells and 33% of them proved positive against HSA.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bit.260370814
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  • 10
    Digitale Medien
    Digitale Medien
    Capacitive moisture sensor devices from plasma films (1986)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 31 (1986), S. 2473-2481 
    Details
    ISSN: 0021-8995
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Maschinenbau , Physik
    Notizen: Polymeric films were deposited on Al2O3 ceramic substrates by plasma deposition from trimethylsilyldimethylamine (TMSDMA) and bis(dimethylamino)methylvinylsilane (BDMAMVS), and their capacitance-relative humidity characteristics investigated. Films doped with methylbromide showed a linear dependence of log(capacitance) with relative humidity over the range 20-90% suggesting application on a moisture sensor device. Hysterisis effects were negligible and the response time was within 1 min.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/app.1986.070310808
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