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  • Chemistry  (3)
  • Beijing Man site  (1)
  • Complement  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Membrane attack complex of complement in Henoch-Schönlein purpura skin and nephritis (1990)
    Springer
    Archives of dermatological research 282 (1990), S. 183-187 
    Details
    ISSN: 1432-069X
    Schlagwort(e): Henoch-Schönlein purpura ; Complement ; Cytolysis ; Endothelial cell damage
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The present study using direct immunofluorescence with monoclonal antibodies to C5b-9 complex-related antigens was undertaken to determine whether complement activation in Henoch-Schönlein purpura (HSP) causes assembly of the membrane attack complex of complement (MAC) in skin and nephritis lesions. The deposition of C5, C6, C7, C8, C9, and C5b-9 neoantigens was noted in the vascular walls of papillary dermis and/or subpapillary dermal plexus of the vessels in 11 out of 15 patients with HSP. Their presence in vessel walls indicates complement activation which leads to terminal complement activation. There were small deposits of S protein at the same sites in three of the 11 skin specimens. Thus, the majority of C5b-9 demonstrated in HSP skin was the cytolytically active C5b-9 complex, MAC. Granular deposits of C5b-9 related antigens without S protein were also found in the capillary walls and mesangium of the glomeruli of two out of four specimens from patients with HSP nephritis; in the other two S protein was colocalized with the deposition of C5b-9. The results of the present study indicate that complement activation leading to generation of MAC may possibly be involved in the pathogenesis of vascular injury in a significantly large number of skin lesions and of HSP nephritis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00372620
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  • 2
    Digitale Medien
    Digitale Medien
    Restudy of the upper age limit of Beijing Man site (1993)
    Springer
    International journal of anthropology 8 (1993), S. 95-98 
    Details
    ISSN: 1824-3096
    Schlagwort(e): Beijing Man site ; stalagmitic flowstone calcite ; uranium-series dating
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract The chronological position of Beijing Man site was restudied by U-series dating of two calcite samples taken from a stalagmitic flowstone layer intercalated in 1–2 layers. Based on the weighted mean of three measurements performed on the purer one, the upper age limit of this site be 421 −54 +110 ka B.P., much greater than former evaluation of 230 ka based on U-series dating of fossil bones. The reliability of the obtained results was discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02447617
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  • 3
    Digitale Medien
    Digitale Medien
    Copper bilirubinate and black pigment gallstone (1995)
    New York, NY [u.a.] : Wiley-Blackwell
    Biospectroscopy 1 (1995), S. 149-156 
    Details
    ISSN: 1075-4261
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Physik
    Notizen: A series of copper bilirubinate complexes (CuBR) was synthesized in solution and in solid state to mimic the black color of the black-pigment gallstone and to explore the formation mechanism of the gallstonein vitro. The variation of the copper contents of these samples indicated that CuBR also exhibits nonstoichiometric characteristics from the FTIR study, i.e., both the so-called acid and neutral copper complex moieties exist in CuBR. The NH groups in pyrrole and lactam groups of bilirubin (H2BR) are binding to the copper ions. An EPR study demonstrates the generation of free radicals and the variation of its electronic structure and conjugation system in the skeleton of H2BR molecule during complex formation. A polymer of CuBR may form through the reaction of H2BR with copper ions. © 1995 John Wiley & Sons, Inc.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bspy.350010209
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  • 4
    Digitale Medien
    Digitale Medien
    A spectroscopic study of pigment gallstones in China (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Biospectroscopy 3 (1997), S. 371-380 
    Details
    ISSN: 1075-4261
    Schlagwort(e): brown pigment stone ; PAGE ; mid-IR spectroscopy ; far IR spectroscopy ; FT-Raman ; bezoar ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Physik
    Notizen: Spectroscopic studies of various types of gallstones carried out in China are reviewed. Three basic classes of gallstones are surveyed: cholesterol stones, brown pigment stones, and black pigment stones. The emphasis of this review is on brown gallstones. The primary spectroscopic methods used in the studies surveyed are Fourier transform infrared absorption and Fourier transform Raman scattering. Chemical components studied in gallstones include cholesterol, bile pigments, glycoproteins, proteins, bilirubin metal complexes, and salts of calcium and other metals. Further studies are needed characterize the relationship of these components to more complex features of gallstones. © 1997 John Wiley & Sons, Inc. Biospectroscopy 3: 371-380, 1997
    Zusätzliches Material: 13 Ill.
    Materialart: Digitale Medien
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  • 5
    Digitale Medien
    Digitale Medien
    A spectroscopic investigation of the formation mechanism of pigment gallstones (1997)
    New York, NY [u.a.] : Wiley-Blackwell
    Biospectroscopy 3 (1997), S. 381-391 
    Details
    ISSN: 1075-4261
    Schlagwort(e): black pigment gallstone ; FTIR ; EPR ; nonlinear phenomena ; vibrational mode ; Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Physik
    Notizen: Further spectroscopic studies of gallstones are reviewed with an emphasis on the formation of black pigment gallstones. This type of gallstone appears mainly in Western countries, with only 3% of the cholelithiasis patients in China having black gallstones. Fourier transform infrared absorption and electron paramagnetic resonance are used as spectroscopic probes of gallstones and their metal bilirubinate components. Nonlinear phenomena in gallstone formation were investigated through the appearance of ring structure in gallstones and fractal patterns in the formation in the precipitates of bile salt systems. Although a complete understanding of gallstone formation has not yet been achieved, interesting progress toward this goal has been made recently. © 1997 John Wiley & Sons, Inc. Biospectroscopy 3: 381-391, 1997
    Zusätzliches Material: 12 Ill.
    Materialart: Digitale Medien
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