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  • CD4-specific (T-lymphocyte) antibodies  (1)
  • Chemistry  (1)
  • Cytofluorometry  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    Comparative analysis of the influences of IL-1, IL-3 and GM-CSF on the commitment of granulocyte-macrophage progenitors in vitro (1991)
    Springer
    Annals of hematology 63 (1991), S. 242-248 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Hematopoiesis ; GM-CSF ; IL-3 ; IL-1 ; Precursor cells ; Cytofluorometry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Our experiments were directed towards the detection of the influence of interleukin-1 (IL-1); interleukin-3 (IL-3), and granulocyte-macrophage colonystimulating factor (GM-CSF) on the generation of granulocyte-macrophage progenitor cells. We also set out to examine whether this process is connected with changes within the early precursor cell compartment. Bone marrow suspension cultures (12 days) supplemented with these cytokines were tested for the presence of GM colony-forming cells (GM-CFC) in a colony-forming unit assay. The percentage of CD 34+ and HLA-DR+ as well as the number of blasts and promyelocytes were estimated cytofluorometrically and morphologically. The proliferative effect of GM-CSF was associated with a net increase of GM-CFC and HLA-DR+ myeloid cells and a decrease in the percentage of CD 34+ early precursor cells. IL-3 acted similarly and also caused an absolute decrease of CD 34+ cells in the cultures. IL-1 did not stimulate the generation of blasts or GM-CFC but elevated the number of CD 34− as well as HLA-DR-expressing cells in the cultures. These results imply that GM-CSF supported the maintenance of hematopoiesis in vitro. The transition from early precursor cells to committed myeloid progenitor cells (GM-CFC) and more mature precursor cells (G-CFC, M-CFC) may be supported by GM-CSF without affecting the self-renewing capacity of CD 34+ early precursors. In contrast, the blast-generating and proliferation-inducing action of IL-3 is associated with a drop in the total number of CD 34+ stem cells. An efficient renewal of this population obviously depends on the presence of IL-1.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01698372
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Imaging rheumatoid arthritis specifically with technetium 99m CD4-specific (T-helper lymphocytes) antibodies (1990)
    Springer
    European journal of nuclear medicine 17 (1990), S. 156-159 
    Details
    ISSN: 1619-7089
    Schlagwort(e): Immunoscintigraphy ; Technetium 99m-labelled antibodies ; CD4-specific (T-lymphocyte) antibodies ; Rheumatoid arthritis ; Localisation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract CD4 expressing T-lymphocytes are involved in the pathogenesis of rheumatoid arthritis, so the possibility of using radiolabelled CD4-specific antibodies to localise diseased joints was studied. Prospectively six patients with rheumatoid arthritis were investigated. Five of them received 200–300 μg of a 555 MBq technetium 99m CD4-specific antibody (MAX.16H5) and were examined with three phase bone scans. Max.16H5 (IgG1) was labelled according to the mercaptoethanol (Schwarz) method. Lymphocytes of one patient were isolated on a Ficoll-Hypaque gradient and labelled with the antibody in vitro. Scans were performed 1.5 h, 4 and 24 h post injection in anterior and posterior views. In all patients, diseased joints could be clearly imaged at as early as 1.5 h. The localisation of the diseased joints correlated (P〈0.01) with the clinical signs, with the early methylene diphosphonate (MDP) scan (P 〉 0.01) and only weakly with the late bone scan (P 〉 0.05). According to these data we conclude that99mTc-labelled CD4-specific antibodies specifically image actively diseased joints in rheumatoid arthritis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00811445
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Computations of ESR Coupling Constants in Organic Radicals. II. Nitro derivatives of the phenyl radical (1988)
    Weinheim : Wiley-Blackwell
    Propellants, Explosives, Pyrotechnics 13 (1988), S. 163-167 
    Details
    ISSN: 0721-3115
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: We compute the ESR coupling constants and the geometries of a set of nitro derivatives of the phenyl radical. We consider the three mononitrophenyls, the six dinitrophenyls and 2,4,6-trinitrophenyl. The computations are based on the use of the Gaussian 82 Program Package with the STO-3G basis set. There are no experimental data available.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/prep.19880130602
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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