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  • 1
    ISSN: 1432-0584
    Schlagwort(e): Acute promyelocytic leukemia ; Reverse transcriptase polymerase chain reaction ; Minimal residual disease ; Promyelocytic leukemia ; Retinoic acid receptorα
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The PML/RARα fusion RNA can be detected in acute promyelocytic leukemia (APL), cytogenetically characterized by the translocation t(15; 17). Our study included ten newly diagnosed patients with APL who were investigated during the course of their diseases using reverse transcription polymerase chain reaction (RT-PCR). At diagnosis, aberrant fragments with a size heterogeneity due to alternative spliced products were detected in all patients, we observed breakpoints within bcr3 (short type) in two patients and bcr1 and 2 breakpoints (long type) in eight patients. Treatment consisted of all-trans retinoic acid (ATRA) in all patients; six patients received simultaneous cytostatic therapy during remission induction. At the time of complete hematological remission (CR), only two patients showed a negative RT-PCR result; eight of the ten patients were still PCR positive when nested primers were used. Subsequently, eight patients received consolidation chemotherapy and became PCR negative. Seven of eight patients are in continuous complete remission (median remission duration: 21 months, range: 11+−26+ months). One patient of the chemotherapy group became PCR positive after 4 months in complete remission and relapsed after 6 months. The remaining two patients who were treated only with ATRA relapsed, received induction chemotherapy, and are in second and third complete remission, respectively. In conclusion, PCR negativity can be achieved only by chemotherapeutic consolidation; patients treated with ATRA alone remain PCR positive. Relapse is always preceded by a positive PCR result. Surprisingly, also patients without measurable PML/ RARα-mRNA in sequential analyses after cytostatic treatment became PCR positive and experienced relapse.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    ISSN: 1432-0584
    Schlagwort(e): Key words Acute promyelocytic leukemia ; Reverse transcriptase polymerase chain reaction ; Minimal residual disease ; Promyelocytic leukemia ; Retinoic acid receptor α
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  The PML/RARα fusion RNA can be detected in acute promyelocytic leukemia (APL), cytogenetically characterized by the translocation t(15; 17). Our study included ten newly diagnosed patients with APL who were investigated during the course of their diseases using reverse transcription polymerase chain reaction (RT-PCR). At diagnosis, aberrant fragments with a size heterogeneity due to alternative spliced products were detected in all patients, we observed breakpoints within bcr3 (short type) in two patients and bcr1 and 2 breakpoints (long type) in eight patients. Treatment consisted of all-trans retinoic acid (ATRA) in all patients; six patients received simultaneous cytostatic therapy during remission induction. At the time of complete hematological remission (CR), only two patients showed a negative RT-PCR result; eight of the ten patients were still PCR positive when nested primers were used. Subsequently, eight patients received consolidation chemotherapy and became PCR negative. Seven of eight patients are in continuous complete remission (median remission duration: 21 months, range: 11+–26+ months). One patient of the chemotherapy group became PCR positive after 4 months in complete remission and relapsed after 6 months. The remaining two patients who were treated only with ATRA relapsed, received induction chemotherapy, and are in second and third complete remission, respectively. In conclusion, PCR negativity can be achieved only by chemotherapeutic consolidation; patients treated with ATRA alone remain PCR positive. Relapse is always preceded by a positive PCR result. Surprisingly, also patients without measurable PML/RARα-mRNA in sequential analyses after cytostatic treatment became PCR positive and experienced relapse.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 19 (1988), S. 289-294 
    ISSN: 0933-5137
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Beschreibung / Inhaltsverzeichnis: Test Methods and Dimensioning of Tribologically Loaded PartsOwing to the complexity of tribological systems the testing of wear components is of particular significance. Here is an effort to show the advantages and disadvantages of product tests, component tests and model tests. Even with model tests good results for the products are attainable when relevant parameters are systematically varied. Hereto some examples are given.
    Notizen: Wegen der Komplexität tribologischer Systeme ist die Prüfung verschleißbeanspruchter Bauteile von besonderer Bedeutung. Es werden die Vor- und Nachteile der Erzeugnisprüfung, der Bauteilprüfung und der Modellprüfung aufgezeigt. Auch mit Modellprüfungen kann man für die Praxis gute Ergebnisse erzielen, wenn man relevante Parameter systematisch variiert. Hierzu werden einige Beispiele gezeigt.
    Zusätzliches Material: 11 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 20 (1989), S. 14-20 
    ISSN: 0933-5137
    Schlagwort(e): Chemistry ; Polymer and Materials Science
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Beschreibung / Inhaltsverzeichnis: Fretting Wear The characteristic feature of fretting wear compared with other types of wear lies in the intensive interactions between transfer of debris, mode of vibration and wear. In particular, the forms of wear are heavily dependent on the continued presence or removal of the resulting wear particles and on the accessibility to lubricants. The systematic treatment of the individual forms of wear facilitates the analysis in cases of damage. Despite the system dependence of wear, the methods of the test chain and of parameter variation makes it possible to achieve practical test results also with component and model tests. An example shows how the quality of tribologically stressed components can be systematically improved in this way.
    Notizen: Das charakteristische Merkmal der Verschleißart Schwingungsverschleiß gegenüber anderen Verschleißarten ist die intensive Wechselwirkung zwischen Stofftransport, Schwingungsform und Verschleiß. Insbesondere die Verschleißerscheinungsformen werden stark vom Verbleib oder Abtransport der entstehenden Verschleißpartikel und den Schmierstoffzutrittmöglichkeiten beeinflußt. Eine systematische Behandlung der einzelnen Verschleißerscheinungsformen erleichtert die Analyse von Schadensfällen. Trotz der Systemabhängigkeit des Verschleißes bieten die Methoden der Prüfkette und der Variation der Parameter die Möglichkeit, auch mit Bauteil- und Modelltests praxisnahe Prüfergebnisse zu erzielen. In einem Beispiel wird gezeigt, wie man damit die Qualität tribologisch beanspruchter Bauteile systematisch erhöhen kann.
    Zusätzliches Material: 15 Ill.
    Materialart: Digitale Medien
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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