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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 68 (1996), S. 224-228 
    ISSN: 1432-1246
    Keywords: Key words Hodgkin’s disease ; Occupational exposure ; Nested case-control study.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The objective of this study was to identify occupational exposures that might be etiologically linked to an unusual cluster of ten cases of Hodgkin’s disease. The cases were identified within the active workforce of a large chemical manufacturing firm over a 23-year period by the medical director of the facilities. Based on comparison with regional cancer incidence rates, the standardized incidence ratio for Hodgkin’s disease was 497 (95% confidence interval: 238–915) for the period from the construction of the facilities in 1966 through early 1992. A nested case-control study was undertaken with 200 controls selected according to case-cohort sampling. Simultaneously, efforts were initiated to confirm and characterize each case more fully. Occupational exposures were identified and categorized using process, work history, medical record, and industrial hygiene data. Tissue slides were available for eight cases and a second review confirmed the diagnosis of Hodgkin’s disease. For one case, a final diagnosis of large-cell anaplastic lymphoma was determined after histology review. Among 214 different chemical agents studied, eight were identified to which three or more of the cases had been exposed prior to the date of their initial diagnosis. Exposure odds ratios were statistically elevated for five of these agents; dose-response evaluations for two of the agents, ethylene oxide and benzene, failed to provide additional support for a causal relationship. In conclusion, although several statistical associations were identified, no substance emerged as a likely candidate for explaining the observed Hodgkin’s disease cluster.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    International archives of occupational and environmental health 68 (1996), S. 224-228 
    ISSN: 1432-1246
    Keywords: Hodgkin's disease ; Occupational exposure ; Nested case-control study
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objective of this study was to identify occupational exposures that might be etiologically linked to an unusual cluster of ten cases of Hodgkin's disease. The cases were identified within the active workforce of a large chemical manufacturing firm over a 23-year period by the medical director of the facilities. Based on comparison with regional cancer incidence rates, the standardized incidence ratio for Hodgkin's disease was 497 (95% confidence interval: 238–915) for the period from the construction of the facilities in 1966 through early 1992. A nested case-control study was undertaken with 200 controls selected according to case-cohort sampling. Simultaneously, efforts were initiated to confirm and characterize each case more fully. Occupational exposures were identified and categorized using process, work history, medical record, and industrial hygiene data. Tissue slides were available for eight cases and a second review confirmed the diagnosis of Hodgkin's disease. For one case, a final diagnosis of large-cell anaplastic lymphoma was determined after histology review. Among 214 different chemical agents studied, eight were identified to which three or more of the cases had been exposed prior to the date of their initial diagnosis. Exposure odds ratios were statistically elevated for five of these agents; dose-response evaluations for two of the agents, ethylene oxide and benzene, failed to provide additional support for a causal relationship. In conclusion, although several statistical associations were identified, no substance emerged as a likely candidate for explaining the observed Hodgkin's disease cluster.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 18 (1974), S. 2935-2944 
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The adhesive bonding of a fast-setting system consisting of three different monomers to etched human enamel surfaces was investigated. Combinations of MMA, methacrylic acid, and adducts of glycidyl methacrylate and p-substituted phenols have been employed. Best results were obtained with hydrogen or t-butyl-substituted phenols. It is shown that a well-chosen three-component system has the advantage of a very low initial viscosity and fast setup times over two-component systems. Various compositions of three-component systems were studied. The maximum bond strength between enamel surfaces and the polymer was 80 kg/cm2. Setup times as well as in vivo setup times are reported.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 20 (1986), S. 773-784 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: To determine whether the surface free energy of polymer materials influences the spreading and growth of cells, surface free energies of 13 polymers and glass were related to spreading and growth of human skin fibroblasts. Experiments were performed in both the presence and absence of serum proteins. We calculated the surface free energy from contact angles of phosphate-buffered saline (PBS), n-propanol/PBS mixtures, and α-bromonaphthalene on the polymers, using the concept of polar and dispersion components accounting for spreading pressures. Cell spreading and substratum surface free energy (γs) showed a characteristic sigmoid relationship both in the presence and in the absence of serum proteins; good spreading only occurred when γs was higher than approximately 57 erg · cm-2. In the presence of serum proteins, cell spreading is similar on most materials; only few materials show relatively high cell spreading. Cell growth in the presence of serum proteins did not differ significantly on the various polymers with reference to their γs values. In contrast, two groups of polymers could be distinguished in the absence of serum with respect to cell growth. The first group showed increasing γs, whereas the second group showed consistently low cell growth. The results demonstrate the complex relationship between cell spreading and substratum surface free energy as well as the role of serum proteins in modifying the surface characteristics of polymers in relation to cell spreading and growth.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 17 (1983), S. 637-641 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: In this study, the dispersion (γsd) and polar (γsp) surface free energies of human enamel with and without an acquired enamel pellicle and of crystalline hydroxyapatite were determined from contact angle measurements. The results show that γsp is strongly influenced by the presence of a pellicle; the total surface free energy (γs) is considerably smaller for enamel with an acquired pellicle than for enamel without an acquired pellicle. Enamel without an acquired enamel pellicle shows surface free energies comparable with those of crystalline hydroxyapatite.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Cell spreading and cell division rates of a transformed line of mouse lung fibroblasts were studied on various polymer surfaces in the presence of serum proteins. The bare polymer surfaces, as well as the protein-coated surfaces, were characterized by their polar (γsp) and dispersion (γsd) surface free energies. Cell spreading appeared to be dependent on the polar surface free energy. Cell spreading is low when the γsp of the bare surface is lower than 5 erg cm-2; marked spreading occurs when γsp is higher than 15 erg cm-2. A similar relationship was found between cell spreading and polarity of the protein-coated surfaces, although less pronounced than for the bare surfaces. Cell spreading appeared independent of the dispersion surface free energy. Cell division rate was the same on all surfaces tested.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Chichester [u.a.] : Wiley-Blackwell
    Journal of Raman Spectroscopy 19 (1988), S. 13-21 
    ISSN: 0377-0486
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The position and broadening of the Raman band associated with the phosphate symmetric stretching vibration in hydroxyapatite are simulated using a simple inter- and intra-ionic potential. The results are compared with experimental values. This comparison was made as a function of the incorporation of carbonate ions in the lattice for a number of substitution models. The line width of the phosphate symmetric stretching vibration is shown both theoretically and experimentally to be dependent on the carbonate content. Good agreement between calculations and experiment is obtained. The results of the calculations offer some support to the suggestions in the literature that the dielectric constant has to be considered as a function of the distance in the lattice, increasing beyond the first environmental layer.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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