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In vivo binding characteristics of carbamazepine and carbamazepine-10, 11-epoxide to serum proteins in paediatric patients with epilepsy (1993)

Kodama, Y. ; Tsutsumi, K. ; Kuranari, M. ; [et al.]

Springer

European journal of clinical pharmacology 44 (1993), S. 291-293

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ISSN: 1432-1041

Keywords: Carbamazepine ; Paediatric patient ; Epilepsy ; carbamazepine-10,11-epoxide ; specific-nonspecific binding ; protein binding ; age effect

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary The in vivo serum protein binding characteristics of carbamazepine (CBZ) and carbamazepine-10,11-epoxide (CBZ-E) were assessed in sera from 23 paediatric patients on CBZ monotherapy. We assumed that CBZ and CBZ-E binding to serum proteins comprised specific binding sites on α1-acid glycoprotein (AAG) and non-specific binding sites on serum albumin. Therefore, the binding characteristics of each compound were analysed according to specific and nonspecific binding equations. Association constants for drug-AAG binding were 0.096 l·μmol−1 for CBZ and 0.023 l·μmol−1 for CBZ-E. Within the concentration ranges investigated the specific binding of each compound contributes to the drug-serum protein interactions. Age did not show a significant correlation with the serum unbound fraction of each compound.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00271375

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A new coupling agent for composite materials: 4-Methacryloxyethyl trimellitic anhydride (1982)

Atsuta, M. ; Abell, A. K. ; Turner, D. T. ; [et al.]

Hoboken, NJ : Wiley-Blackwell

Journal of Biomedical Materials Research 16 (1982), S. 619-628

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ISSN: 0021-9304

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Medicine , Technology

Notes: Composite materials were made by sedimention of ceramic powders in methyl methacrylate which was then polymerized by γ-irradiation. Inclusion of 4-methacryloxyethyl trimellitic anhydride (4-META) generally was found to result in an increase in Knoop hardness number, Young's modulus, and transverse strength. Most emphasis was placed on transverse strength which was found to be increased by ca. 30% by inclusion of 4-META (5 wt %) in composites made with silanated LiAlSiO4.However an abrupt decrease in strength was found for composites with greater than ca. 83 wt % silanated LiAlSiO4. This was shown by fractography to be due to increased porosity and dewetting at the higher filler contents. Fractography also indicated that inclusion of 4-META results in a more coherent polymeric matrix. Further evidence for greater coherence was obtained by showing that 4-META confers resistance to disintegration by chloroform.

Additional Material: 8 Ill.