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Digitale Medien

Continuous enzyme-catalyzed production of 6-aminopenicillanic acid and product concentration by reverse osmosis (1995)

Danzig, Joachim ; Tischer, Wilhelm ; Wandrey, Christian

Weinheim : Wiley-Blackwell

Chemical Engineering & Technology - CET 18 (1995), S. 256-259

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Details

ISSN: 0930-7516

Schlagwort(e): Chemistry ; Industrial Chemistry and Chemical Engineering

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: The efficiency of 6-aminopenicillanic acid (6-APA) production by enzyme-catalyzed hydrolysis of penicillin G using penicillin G amidase (E. C. 3.5.1.11) immobilized in polyacrylamide gel can be improved by using a lower substrate concentration and an optimized low buffer concentration. In a continuous process the combination of a stirred-tank reactor and a plug-flow reactor gives optimum productivity. Since precipitation of 6-APA is the crucial step in downstream processing, the product concentration has to be as high as possible. This can be achieved by concentrating the product solution by reverse osmosis.

Zusätzliches Material: 6 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/ceat.270180406

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