ISSN:
1432-2072
Keywords:
Drug self-administration
;
Amobarbital
;
Pentobarbital
;
Secobarbital
;
Clonazepam
;
Clorazepate
;
Diazepam
;
Flurazepam
;
Medazepam
;
Midazolam
;
Chlorpromazine
;
Cocaine
;
Baboons
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Self-injection of three barbiturates, six benzodiazepines, and chlorpromazine was examined in baboons. Intravenous injections of drug were dependent upon completion of 160 lever presses (a 160-response fixed-ratio schedule). A 3-h time-out period followed each injection, permitting a maximum of eight injections per day. Prior to testing each dose of drug, self-injection performance was established with cocaine. Subsequently, a test dose was substituted for cocaine. Amobarbital, pentobarbital, and secobarbital maintained the highest levels of self-injection, which were similar to those maintained by cocaine. Clonazepam, clorazepate, diazepam, flurazepam, medazepam, and midazolam maintained relatively modest levels of self-injection, while chlorpromazine maintained only low levels, which were in the range of vehicle control. Of the six benzodiazepines, midazolam produced the highest levels of self-injection. At the highest self-injected doses, the barbiturates produced anesthesia in contrast to the benzodiazepines, which produced only sedation. None of the drugs affected food intake except for chlorpromazine, which produced dose-related decreases. The differences among the drug classes (i.e., barbiturate, benzodiazepine, phenothiazine) with respect to the maintenance of self-injection correspond well with the results of previous animal and human drug self-administration studies.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00432169
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