ISSN:
1432-1920
Keywords:
Chlorpromazine
;
contrast media
;
interaction
;
neurotoxicity
;
subarachnoid injection
;
subdural injection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary During a 14-day period, 45 of 78 rabbits were treated intravenously with chlorpromazine (5 mg kg-1 day-1). Metrizamide or iohexol was injected subarachnoidally and the neurotoxic effects of each substance on rabbit behaviour were evaluated for 3 h in both chlorpromazine-treated and non-treated rabbits. Chlorpromazine increased both the excitative and the depressive effects of metrizamide and the depressive effects of iohexol. No signs of excitation were observed in chlorpromazine-treated and non-treated rabbits after subarachnoid injections of iohexol. In spite of a free flow of clear fluid from the needle both before and after the intended subarachnoid injection, radiography disclosed that 26 of 67 suboccipital injections inadvertently resulted in a subdural deposition of the contrast medium. Contrast medium effects following subdural injection significantly differed from those following subarachnoid injection.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00342420
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