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  • 1
    Electronic Resource
    Electronic Resource
    Makroglobulinbildende chronische lymphatische Leukämie ohne Makroglobulinämie (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 389-396 
    Details
    ISSN: 1432-1440
    Keywords: B-cell lymphoma ; secretory lymphocytes ; defect of secretory mechanism ; cytoplasmic inclusions ; Russell bodies ; IgM ; macroglobulins ; 8 S-IgM-subunits ; polyacrylamid electrophoresis ; radio-immunoprecipitation technique ; single radial immuno-diffusion ; Chronische lymphatische Leukämie ; B-Zellenlymphom ; lymphatische Zellen vom sekretorischen Typ ; Sekretionshemmung ; intracelluläre Einschlüsse ; Russellsche Körperchen ; IgM ; Makroglobuline ; 8 S-IgM-Untereinheiten ; Polyacrylamidelektrophorese ; Radioimmunpräzipitationstechnik ; einfache radiale Immunodiffusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei einem Fall von chronischer lymphatischer Leukämie wurden histologische, cytochemische und elektronenmikroskopische Untersuchungen des Lymphknotens sowie Immunglobulinbestimmungen des Lymphknotenhomogenates und des Blutes durchgeführt. Die Immunglobulinbestimmungen deckten eine hochgradige IgM-Vermehrung im Lymphknoten bei IgM-Verminderung im Blut auf. Ein morphologisches Äquivalent dieser IgM-Vermehrung stellte die Ablagerung PAS-positiver Cytoplasmaeinschlüsse in den neoplastischen Lymphknotenzellen dar. Diese Einschlüsse waren in Ergastoplasmasäcken dieser Zellen lokalisiert. Im übrigen beherrschten ergastoplasmahaltige „sekretorische“ lymphatische Zellen ohne cytoplasmatische Einschlüsse das elektronenmikroskopische Bild. Es handelte sich also um ein IgM-bildendes B-Zellenlymphom vom sekretorischen Typ. Die unterbliebene Abgabe der Makroglobuline in das Blut ist als Sekretverhaltung zu deuten. Da das IgM als 8 S-IgM im Gewebe vorlag, nehmen wir an, daß hier eine Polymerisationsstörung der IgM-Untereinheiten zu dem 19 S-Pentamer bestand, als deren Folge die unterbliebene Sekretion von IgM ins Blut anzusehen ist.
    Notes: Summary A lymph node of a patient suffering from chronic lymphocytic leukemia was investigated using histological, cytochemical and electron microscopic techniques. The remaining lymph node tissue and the blood were also examined for their immunoglobulin content. The immunoglobulin analysis revealed an excessive increase of IgM in the lymph node, while there was a reduced serum IgM level. A morphological equivalent of the increased IgM was constituted by the deposit of PAS-positive cytoplasm inclusions, which were embedded in distended cisternae of the ergastoplasm of the neoplastic lymph node cells. “Secretory” lymphatic cells containing ergastoplasm without inclusion bodies otherwise dominated the electron microscopic picture. The existence of a B-cell lymphoma producing IgM of the secretory type is thus demonstrated. The lack of emission of IgM into the blood has to be interpreted as the result of a defect in the secretory mechanism. As the IgM was found in the form of 8 S-IgM in the tissue, it can be assumed that a disturbance of the polymerisation of the IgM-subunits into the 19 S-pentamer existed, the result of which was the absence of secretion of IgM into the blood.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468087
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  • 2
    Electronic Resource
    Electronic Resource
    Technique and result of intraoperative choledochoscopy (1987)
    Springer
    Surgical endoscopy and other interventional techniques 1 (1987), S. 51-54 
    Details
    ISSN: 1432-2218
    Keywords: Choledochoscopy ; Choledochoscope ; Bile duct examination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The use of intraoperative choledochoscopy represents a significant advance in biliary surgery. Flexible instruments are ideal for examining the intrahepatic bile ducts, while rigid instruments are best suited for the extrahepatic ductal system. The cystic duct stump may be occasionally used for access, but, as a rule, a supraduodenal choledochotomy is necessary. Our experience with 776 examinations is reported. A total of 348 patients (44.8%) had ductal stones. In 10 patients (2.8%), a stone was overlooked. Equivocal cholangiograms, ductal stones, and obstructive tumors constitute the most important indications for endoscopic examination.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00703088
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    100. Die intraoperative Gallengangsendoskopie (1977)
    Springer
    Langenbeck's archives of surgery 345 (1977), S. 582-582 
    Details
    ISSN: 1435-2451
    Keywords: Choledochoscopy ; Endoscopy, operative biliary ; Biliary stones ; Choledochoskopie ; intraoperative Gallengangsendoskopie ; GallengangBteine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: ZusammenfaBung Erfahrungsbericht von 189 intraoperativen Gallengangsendoskopien mit einem neuen starren Kaltlichtinstrument (Herst.: Fa. Storz, Tuttlingen). Folgende ErgebniBe wurden gewonnen: 91mal (= 48,7%) Nachweis von 1-27 Konkrementen im Gallengang, 77mal (= 40,7%) kein pathologischer Befund, 15mal (= 7,9%) mittlere bis schwere Cholangitis und 7mal Gallengangs- bzw. Pankreaskopftumor. Die wesentlichen Vorteile bestehen in der ungefährlichen Handhabung, in der Kontrolle des Choledochus auf Steinfreiheit und in der Möglichkeit der Biopsieentnah me unter Sicht.
    Notes: Summary Report of 189 operative biliary endoscopies with a new rigid endoscope (Storz, Tuttlingen, FR Germany). Results: In 91 patients (= 48.7%) we found 1-27 stones in the choledochus, in 77 (= 40.7%) no pathologic changes in the choledochus, in 15 (= 7.92%) a cholangitis of medium to severe degree and in 7 (= 3.7%) a tumor of the choledochus or pancreas. The main advantages of the new operative biliary endoscopy are harmleB management, supervision of the choledochus in terms of stones, and the poBibility of taking a biopsy under control of the eye.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01305544
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    Paper (German National Licenses)
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