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  • 1
    Electronic Resource
    Electronic Resource
    192 IgG-saporin (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 519-526 
    Details
    ISSN: 1432-0533
    Keywords: Astrocyte ; Cholinergic ; Immunotoxin ; Microglia ; Nerve growth factor receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have previously shown that an immunotoxin (IT) directed against the p75 component of the nerve growth factor receptor (NGFr) selectively abolished cholinergic neurons in the basal forebrain of the rat following intraventricular administration. We now report the neuropathological responses in the rat brain to the IT, with particular emphasis on the cholinergic basal forebrain (CBF) and other known p75NGFr-positive brain regions. Animals received intraventricular injections of IT and were allowed to survive for various times. Sections through the entire brain were evaluated using (1) hematoxylin and eosin; (2) glial fibrillary acidic protein immunohistochemistry; and (3)Griffonia simplicifolia lectin histochemistry. The only clearly degenerating cells following IT treatment were located in the CBF or in the Purkinje cell layer of the cerebellum. A marked microglial response was demonstrated that was tightly linked both topographically and temporally to the loss of neurons in these areas. The astroglial response was mild in the same regions in which the microglial response was obvious. The other areas of rat brain including the terminal fields of CBF projections showed no consistent reactive cellular responses in IT-treated animals. This study extends and corroborates previous work indicating speciticity of IT, demonstrates active neuronal degeneration by conventional pathological methods for the first time, and illustrates the unexpected and novel finding that the predominant pathological response to the IT-induced loss of neurons is microglial. Both the high degree of specificity and the distinctive glial response distinguish the IT model from other experimental models of CBF neurodegeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00571506
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    192 IgG-saporin (1995)
    Springer
    Acta neuropathologica 89 (1995), S. 519-526 
    Details
    ISSN: 1432-0533
    Keywords: Key words Astrocyte ; Cholinergic ; Immunotoxin ; Microglia ; Nerve growth factor receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We have previously shown that an immunotoxin (IT) directed against the p75 component of the nerve growth factor receptor (NGFr) selectively abolished cholinergic neurons in the basal forebrain of the rat following intraventricular administration. We now report the neuropathological responses in the rat brain to the IT, with particular emphasis on the cholinergic basal forebrain (CBF) and other known p75NGFr-positive brain regions. Animals received intraventricular injections of IT and were allowed to survive for various times. Sections through the entire brain were evaluated using (1) hematoxylin and eosin; (2) glial fibrillary acidic protein immunohistochemistry; and (3) Griffonia simplicifolia lectin histochemistry. The only clearly degenerating cells following IT treatment were located in the CBF or in the Purkinje cell layer of the cerebellum. A marked microglial response was demonstrated that was tightly linked both topographically and temporally to the loss of neurons in these areas. The astroglial response was mild in the same regions in which the microglial response was obvious. The other areas of rat brain including the terminal fields of CBF projections showed no consistent reactive cellular responses in IT-treated animals. This study extends and corroborates previous work indicating specificity of IT, demonstrates active neuronal degeneration by conventional pathological methods for the first time, and illustrates the unexpected and novel finding that the predominant pathological response to the IT-induced loss of neurons is microglial. Both the high degree of specificity and the distinctive glial response distinguish the IT model from other experimental models of CBF neurodegeneration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00571506
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Ternäre intermetallische Phasen des Lithiums mit Elementen der 4. Neben- und 5. Hauptgruppe mit statistischer Metallverteilung im „Kationen“-TeilgitterProfessor Hanskarl Müller-Buschbaum zum 60. Geburtstage gewidmet (1991)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 597 (1991), S. 33-39 
    Details
    ISSN: 0044-2313
    Keywords: Intermetallic phases (ternary) ; lithium ; 4A metals ; 5B elements ; preparation ; crystal structure ; X-ray ; neutron scattering ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Ternary Intermetallic Phases of Lithium, Transition Metals of the 4th Group and Elements of the 5th Maingroup with Statistical Metal Distribution in the „Cation“-SubstructureThe results of X-ray investigations and neutron diffraction on new and in some cases already known [1, 2] ternary intermetallic phases of Lithium with transition metals of the 4th group (b) and those of the 5th main group (X = P, As, Sb, Bi) will be reported. They crystallize in a partly „filled“ antifluorite type structure with a statistical Li/B-distribution in the tetrahedral sites. The structures are obviously stabilized by small amounts of enclosed d-elements.
    Notes: Es wird über Röntgenstrukturuntersuchungen und Neutronenbeugung an neuen und einigen schon bekannten [1, 2] ternären intermetallischen Phasen des Lithiums mit Elementen der 4. Nebengruppe (B) und Elementen der 5. Hauptgruppe (X = P, As, Sb, Bi) berichtet. Sie kristallisieren in einer teilweise „aufgefüllten“ Antifluorit-Struktur mit statistischer Li/B-Besetzung der Tetraederlücken, die offenbar durch den Einbau von geringen Mengen der Übergangsmetalle stabilisiert wird.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19915970106
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Darstellung und Kristallstruktur von TICu[CuO2] (1991)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 605 (1991), S. 157-162 
    Details
    ISSN: 0044-2313
    Keywords: TICu[CuO2] ; synthesis ; crystal structure ; lattice energy ; Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Preparation and Crystal Structure of TlCu[CuO2]By reaction of Tl2O3 and Cu2O in a sealed copper-type TlCu[CuO2] was synthesized; the orthorhombically bodycentered crystallizing compound forms a new structure type, space group Imma (no. 74), with the lattice constants a = 552.5 pm, b = 605.2 pm, c = 896.4 pm. The Madelung Part of Lattice Energy, MAPLE, as well as Effective Coordination Numbers, ECoN, these via Mean Effective Ionic Radii, MEFIR, were calculated.
    Notes: Durch Umsetzung von Tl2O3 und Cu2O im verschweißten Kupfertiegel gelang die Darstellung von TlCu[CuO2]; die Verbindung kristallisiert orthorhombisch innenzentriert in einem neuen Strukturtyp, Raumgruppe Imma (Nr. 74), mit den Gitterkonstanten a = 552,5 pm, b = 605,2 pm, c = 896,4 pm. Der Madelunganteil der Gitterenergie, MAPLE, sowie Effektive Koordinationszahlen, ECoN, diese über Mittlere Effektive Ionenradien, MEFIR, wurden berechnet.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19916050119
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
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