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Structural wrinkles and the genomic regulatory sites of eukaryotes (1985)

Nussinov, Ruth

Springer

Journal of molecular evolution 22 (1985), S. 150-159

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ISSN: 1432-1432

Keywords: Chromatin structure ; Regulation ; Structural computations

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Summary Calculations of DNA angular parameters in 50 eukaryotic sequences reveal regions of large conformational deviations from ideal DNA around regulatory sites. Frequently, discrete peaks of structural variation are present upstream of genes. Known regulatory regions often include variants of consensus sequences. Thus, imprecise sequences and structures are recognized within large genomic stretches. The existence of structurally “wrinkled” regions in the vicinity of regulatory sequences is likely to facilitate greatly their recognition by proteins and enzymes.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02101693

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