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  • 1
    Digitale Medien
    Digitale Medien
    Analysis of the p53 gene mutations in acute myelogenous leukemia: The p53 gene mutations associated with a deletion of chromosome 17 (1995)
    Springer
    Annals of hematology 71 (1995), S. 83-87 
    Details
    ISSN: 1432-0584
    Schlagwort(e): p53 gene ; Acute myelogenous leukemia ; Chromosome 17 ; Polymerase chain reaction-singlestrand conformation polymorphism ; Direct sequencing
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In order to determine the relevance of the p53 tumor suppressor gene mutations in acute myelogenous leukemia (AML), we analyzed the p53 gene in genomic DNA of 18 unselected cases of AML by polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) and direct sequencing. We detected three cases (16.7%) with the p53 gene mutations showing only the mutant alleles; the high incidence in cases with loss of a whole chromosome 17 (two of three) contrasted with the low incidence in cases without abnormalities of chromosome 17 (one of 15). These cases containing the mutations of the p53 gene showed a poor prognosis. Although we analyzed a rather small series of patients, these findings suggest that the p53 gene mutations might be involved in the progression and prognosis of at least some cases of AML.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01699251
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Analysis of the p53 gene mutations in acute myelogenous leukemia: the p53 gene mutations associated with a deletion of chromosome 17 (1995)
    Springer
    Annals of hematology 71 (1995), S. 83-87 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Key words p53 gene ; Acute myelogenous leukemia ; Chromosome 17 ; Polymerase chain reaction ; single-strand conformation polymorphism ; Direct sequencing
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  In order to determine the relevance of the p53 tumor suppressor gene mutations in acute myelogenous leukemia (AML), we analyzed the p53 gene in genomic DNA of 18 unselected cases of AML by polymerase chain reaction–single-strand conformation polymorphism (PCR–SSCP) and direct sequencing. We detected three cases (16.7%) with the p53 gene mutations showing only the mutant alleles; the high incidence in cases with loss of a whole chromosome 17 (two of three) contrasted with the low incidence in cases without abnormalities of chromosome 17 (one of 15). These cases containing the mutations of the p53 gene showed a poor prognosis. Although we analyzed a rather small series of patients, these findings suggest that the p53 gene mutations might be involved in the progression and prognosis of at least some cases of AML.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01699251
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
  • 3
    Digitale Medien
    Digitale Medien
    Comparative platelet anti-aggregant activity of D-cysteinolic acid analogues (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 1110-1112 
    Details
    ISSN: 1420-9071
    Schlagwort(e): D-Cysteinolic acid ; platelet aggregation ; inhibitor ; marine product ; 2-aminoethyl disulfide ; sardine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary D-Cysteinolic acid (1) analogues with an S-C-C-N skeleton showed increased platelet anti-aggregant activity in the following order: 2-aminoethanesulfonic acids, thiazolidines, 2-aminoethanethiols and 2-aminoethyl disulfides. Methyl substitutions at the 2-position potentiated the activity. Of these analogues, bis [(R)-2-aminopropyl] disulfide was the most potent inhibitor of platelet aggregation, with about 600-fold the activity of (1).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01950172
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Effect of glucose and phloretin-2′-β-D-glucose (phloridzin) on in vitro fertilization of mouse ova (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 398-399 
    Details
    ISSN: 1420-9071
    Schlagwort(e): In vitro fertilization ; mouse ova ; capacitation ; glucose ; phloretin-2′-β-D-glucose (phloridzin)
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The fertilization ratio of mouse ova in vitro decreased when glucose concentration in the medium was lowered. However, the addition of phloretin-2′-β-D-glucose (phloridzin), known as a glucose uptake inhibitor, restored the fertilization ratio back to the control level. The glucose moiety of the phloridzin seemed to be responsible for this effect.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02118625
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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