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  • 1
    Electronic Resource
    Electronic Resource
    Slight impairment of psychomotor skills in children after treatment of acute lymphoblastic leukemia (1984)
    Springer
    European journal of pediatrics 142 (1984), S. 189-197 
    Details
    ISSN: 1432-1076
    Keywords: Acute lymphoblastic leukemia ; Cognitive functions ; Psychomotor speed ; School achievements
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Several studies have reported a decline in intelligence and cognitive functions in survivors of childhood acute lymphoblastic leukemia (ALL). Other investigators, however, have found no intellectual impairment in these children. Fifty-one long-term survivors of ALL, having been treated according to the protocols of the BFM Study Group from 1970 to 1979, were assessed retrospectively using neurophysical methods. The results were compared with those obtained from 30 patients with other malignancies, who had received neither radiation therapy to the central nervous system (CRT) nor any methotrexate during chemotherapy. Additionally, neurological examinations and cranial computed tomography (CCT) were performed. Neuropsychological examinations included verbal functions, intelligence (performance), psychomotor speed, motor skills and sensory integration. The results of verbal tests and the IQs, tested by nonspeed-related measures, were within normal limits in both groups. About one-third of all patients showed mild disturbances of psychomotor speed and motor skills. Children with leukemia had lower scores than those with solid tumors for nearly all tasks, but only tests for sensory integration revealed significant differences between former ALL patients and tumor patients. Furthermore, the following results were obtained related to different therapeutic modalities: (1) The higher total radiation doses had been during CRT (maximum 24 GY), the more neuropsychological functions were impaired, particularly motor accuracy and sensory integration. (2) These disturbances improved with the length of survival. Widening of subarachnoidal space was found in 33% of the CCT obtained. There was no correlation between the intellectual functions of the survivors and the CCT abnormalities. Neurological findings mainly consisted of slight fine motor disturbances. The results of the study suggest that psychomotor functions are more likely to be affected by antineoplastic therapy than are higher cognitive functions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442447
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  • 2
    Electronic Resource
    Electronic Resource
    Über die simultane Bestimmung von Selen und Tellur im unteren ppb-Bereich durch Cathodic-Stripping-Voltammetrie (1979)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 295 (1979), S. 1-6 
    Details
    ISSN: 1618-2650
    Keywords: Best. von Selen neben Tellur ; Voltammetrie, cathodic stripping ; simultan, ppb-Bereich
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Ein Verfahren der »cathodicstripping«-Voltammetrie wird beschrieben zur simultanen Bestimmung von Selen und Tellur im Bereich von 0,2–20 ppb Selen und 0,2–50 ppb Tellur. Die elektrolytische Anreicherung erfolgt potentiostatisch bei −0,4V (SCE) aus (NH4)2SO4-haltiger Grundlösung (pH 4,5) in Gegenwart von ÄDTA und CuCl2 an einem hängenden Quecksilbertropfen. Das Verfahren ist weitgehend störungsfrei und ermöglicht auch die Einzelbestimmung des Selens bzw. Tellurs in Gegenwart eines 104-fachen Überschusses des anderen Partners.
    Notes: Summary A “cathodic-stripping” voltammetric procedure for the determination of selenium and tellurium in the range of 0.2–20 ppb and 0.2–50ppb, respectively, is described. The electrolytical preconcentration on a hanging Hg-droplet is effected potentiostatically at −0.4 V (SCE) from a supporting electrolyte containing (NH4)2SO4 (pH4.5), in the presence of EDTA and CuCl2. The procedure is substantially free of interferences and enables also the single determination of selenium and tellurium in the presence of a 104-fold excess of the corresponding concomitant element.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00490939
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  • 3
    Electronic Resource
    Electronic Resource
    Bestimmung von Arsen im sub-ppb-Bereich durch Differential-Pulse-Cathodic-Stripping-Voltammetrie (1980)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 300 (1980), S. 267-272 
    Details
    ISSN: 1618-2650
    Keywords: Best. von Arsen ; Voltammetrie, cathodic stripping ; Differential-Pulse, sub-ppb-Bereich
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Es wird ein Verfahren zur Bestimmung von As(III)-Spuren durch Differential-Pulse-Cathodic-Stripping-Voltammetrie (DPCSV) beschrieben. Als Arbeitselektrode dient ein hängender Quecksilbertropfen. Die Anreicherung erfolgt bei −0,55 V (Bezugselektrode: Ag/AgCl/KCl ges.) aus 1 N HCl in Gegenwart von CuCl2. Das Elektrolyseprodukt ist vermutlich eine intermetallische Verbindung der Zusammensetzung Cu3As, die auf der Oberfläche des Quecksilbertropfens abgeschieden wird. Die Auflösung durch »cathodic-stripping« auf Grundlage der Weiterreduktion des Arsens zu negativ 3 wertigem Arsen führt zu einem bei −0,77 V bis −0,79 V liegenden Peak, dessen Höhe von 0,2 bis 20 ppb As linear zunimmt. Auf Störeinflüsse wird hingewiesen.
    Notes: Summary A method for the determination of traces of As(III) by differential pulse cathodic stripping voltammetry (DPCSV) is described. The hanging mercury drop electrode (HMDE) is used as working electrode. Preelectrolysis is carried out in 1 N HCl in the presence of CuCl2 at a potential of −0.55 V (reference electrode: Ag/AgCl/KCl sat.). The product formed in the electrolysis is probably an intermetallic compound of the composition Cu3As. It is deposited on the mercury surface. Its redissolution by cathodic stripping on the basis of a further reduction of arsenic to As3− leads to a current signal at a potential between −0.77 V and −0.79 V. The dependence of peak height on concentration of arsenic shows linearity in the range of 0.2 to 20 ppb As. Interfering influences are also reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00469972
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    Paper (German National Licenses)
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