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  • 1
    Digitale Medien
    Digitale Medien
    Plotzlicher Tod bei Urticaria pigmentosa (1990)
    Springer
    International journal of legal medicine 103 (1990), S. 541-546 
    Details
    ISSN: 1437-1596
    Schlagwort(e): Urticaria pigmentosa ; Nettleship Syndrome ; Sudden death, anaphylactoid reaction ; Urticaria pigmentosa ; Nettleship-Syndrom ; plötzlicher Tod, anaphylaktoide Reaktion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Rechtswissenschaft
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Es wird über den plötzlichen Tod eines 25jährigen berichtet, bei dem seit 6 Jahren eine Urticaria pigmentosa bekannt war. Er wurde an einem kalten Novembermorgen auf dem taunassen Rasen tot aufgefunden. Histologisch fanden sich keine Anhaltspunkte für eine systemische Mastozytose. Die biochemischen Untersuchungen (stark erhöhter Histamin-Wert im Urin) erklärten zusammen mit der BAK von 0,72ℵ und der Auffindesituation (Kältereiz) den todlichen Pathomechanismus, eine generalisierte anaphylaktoide Reaktion.
    Notizen: Summary A case of sudden death of a 25-year-old man, with a six years history of Urticaria pigmentosa, is reported. On a cold morning in November he was found lying dead on the lawn. Histology revealed no signs of systemic mastocytosis. The biochemical investigations (high free histamin level in urine) in addition to a BAC of 0,72 mg/g and the scene conditions (cold irritation) explained the mechanism of death, a systemic anaphylactoid reaction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00209161
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  • 2
    Digitale Medien
    Digitale Medien
    Plötzlicher Tod bei Urticaria pigmentosa (1990)
    Springer
    International journal of legal medicine 103 (1990), S. 541-546 
    Details
    ISSN: 1437-1596
    Schlagwort(e): Urticaria pigmentosa ; Nettleship Syndrome ; Sudden death, anaphylactoid reaction ; Urticaria pigmentosa ; Nettleship-Syndrom ; plötzlicher Tod, anaphylaktoide Reaktion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Rechtswissenschaft
    Beschreibung / Inhaltsverzeichnis: Zusammenfassung Es wird über den plötzlichen Tod eines 25jährigen berichtet, bei dem seit 6 Jahren eine Urticaria pigmentosa bekannt war. Er wurde an einem kalten Novembermorgen auf dem taunassen Rasen tot aufgefunden. Histologisch fanden sich keine Anhaltspunkte für eine systemische Mastozytose. Die biochemischen Untersuchungen (stark erhöhter Histamin-Wert im Urin) erklärten zusammen mit der BAK von 0,72 ‰ und der Auffindesituation (Kältereiz) den tödlichen Pathomechanismus, eine generalisierte anaphylaktoide Reaktion.
    Notizen: Summary A case of sudden death of a 25-year-old man, with a six years history of Urticaria pigmentosa, is reported. On a cold morning in November he was found lying dead on the lawn. Histology revealed no signs of systemic mastocytosis. The biochemical investigations (high free histamin level in urine) in addition to a BAC of 0,72 mg/g and the scene conditions (cold irritation) explained the mechanism of death, a systemic anaphylactoid reaction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01254407
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Collagen synthesis in scleroderma: Selection of fibroblast populations during subcultures (1985)
    Springer
    Archives of dermatological research 277 (1985), S. 373-376 
    Details
    ISSN: 1432-069X
    Schlagwort(e): Collagen ; Fibroblast populations ; Scleroderma
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In progressive systemic scleroderma, excessive deposition of collagen leads to fibrosis of several tissues including the skin. It has been found that different populations of fibroblasts are present in scleroderma skin; these can be obtained by establishing cell cultures from different layers of the involved skin. Excessive overproduction of collagen was noted in primary cultures of cells obtained from deeper layers of the skin of patients in an early stage of the disease, whereas control fibroblasts did not manifest significant variations dependent on the layers of skin used to initiate the cultures. The synthesis of type-I and-III collagen was found to be altered concomitantly. The production of collagen and collagenous proteins was then followed during subcultivations of overproducing fibroblasts. In many cell strains, increased synthesis of collagen and/or noncollagenous proteins had already been lost after the first subcultivation, whereas overproduction was stable in others. However, after five passages, most of the cultures showed normal collagen synthesis, which probably indicates a loss of phenotype due to successive subcultures or overgrowth by another population of fibroblasts.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00509236
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  • 4
    Digitale Medien
    Digitale Medien
    Collagen synthesis in generalized morphea (1983)
    Springer
    Archives of dermatological research 275 (1983), S. 393-396 
    Details
    ISSN: 1432-069X
    Schlagwort(e): Collagen ; Localized scleroderma ; Fibroblasts
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Synthesis of collagen and non-collagenous proteins was measured in fibroblast cultures derived from different layers of the dermis from a patient with an early stage of localized scleroderma. Increased synthesis of collagen was found in fibroblasts grown from the subcutaneous fat of this patient, whereas cells obtained from the papillary dermis revealed normal metabolism. These data agree with the results obtained in previous experiments with cells derived from patients with progressive systemic sclerosis in primary culture, thus indicating that the two diseases have a common pathomechanism. Several subcultures of the activated fibroblast populations were also studied. Normal collagen synthesis in these cultures was observed after the fifth passage, probably indicating selection of cell populations or loss of the previous phenotype.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00417340
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  • 5
    Digitale Medien
    Digitale Medien
    Ultrastructural basis for antigen mapping using sodium chloride-separated skin (1991)
    Springer
    Archives of dermatological research 283 (1991), S. 529-532 
    Details
    ISSN: 1432-069X
    Schlagwort(e): Blistering skin diseases ; Antigen mapping ; Split skin studies ; Anchoring filaments ; Subbasal dense plate
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary In many cases of autoimmune blistering skin diseases indirect immunofluorescence with serum of patients on 1 M NaCl-separated skin represents a rapid diagnostic tool before the use of more complicated immunoelectron microscopy. The present study demonstrates that in skin samples from five adults, separated using 1 M NaCl, 0.15 M NaCl and 0.01 M phosphate buffered saline (PBS), the split formed within the lamina lucida at an identical ultrastructural level. The sub-basal dense plate (SDP) with a wreath of anchoring filaments remained on the epidermal side of the split adjacent to the hemidesmosomal part of the plasma membrane of basal keratinocytes. The base of the split blister was constituted from the lamina densa, with a remote possibility of some anchoring filaments attached. We demonstrate that antigens on the roof of the NaCl- or PBS-split blister may be associated, beside intracellular hemidesmosomal structures, with the SDP and basement membrane components between the SDP and the basal keratinocytes as well as with anchoring filaments attached to the SDP. The observations reported here allow a more precise mapping of antigen determinants in blistering skin diseases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00371928
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