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  • Artikel: DFG Deutsche Nationallizenzen  (2)
  • Collagen  (1)
  • Culex pipiens fatigans  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Effect of IL-10 on collagen-induced arthritis in mice (1996)
    Springer
    Inflammation research 45 (1996), S. 283-288 
    Details
    ISSN: 1420-908X
    Schlagwort(e): IL-10 ; Collagen ; Arthritis ; Macrophage
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract In the present study we investigated the effect of a potent anti-inflammatory cytokine, interleukin (IL)-10, on the development of collagen-induced arthritis (CIA) in mice. Each DBA1/J mouse was immunized with 200 μg of native collagen and followed by booster injections at 3 weeks. rmIL-10 was injected i.p. daily at a dose of 100 ng/mouse. Mice were divided into four groups according to the administration period of rmIL-10. As a result, a 48-day course of IL-10 treatment significantly suppressed the severity of arthritis. Among the 4 groups, the most pronounced suppression was observed in the group in which IL-10 was given from day 0 to 21. On the other hand, there were no significant differences in the serum IgG anti-type II collagen (CII) titers between the four groups. Moreover, the production of cytokines (IL-6 and tumor necrosis factor-α (TNF-α)) and other mediators (prostaglandin E2 (PGE2) and nitric oxide (NO)) by peritoneal macrophages seemed to show no clear correlation with the severity of arthritis in mice. These results raise the possibility that IL-10 might be a useful agent for suppressing the progression and the development of CIA in mice.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02280992
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 2
    Digitale Medien
    Digitale Medien
    Absolute configuration of mosquito oviposition attractant pheromone, 6-acetoxy-5-hexadecanolide (1985)
    Springer
    Journal of chemical ecology 11 (1985), S. 643-648 
    Details
    ISSN: 1573-1561
    Schlagwort(e): Mosquito ; Culex pipiens fatigans ; Diptera ; Culicidae ; oviposition ; attractant ; pheromone ; chiral chromatography ; acetoxyhexadecanolide
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract 6-Acetoxy-5-hexadecanolide (Ia) in the oviposition attractant pheromone released from egg apical droplets of the mosquitoCulex pipiens fatigans Wied. is shown to be the (−)-(5R,6S)- enantiomer. Identification was by chromatography of the 6-trifluoroacetoxy derivatives of the natural pheromone and of the synthetic (−)-(5R,6S)- (Ib) and (+)-(5S,6R)- (IIb) enantiomers on a capillary column having a chiral stationary phase comprising a derivative of (1S,3S)-chrysanthemic acid. The synthetic (−)-(5R,6S)- enantiomer (Ia) attracted oviposition of four fold more mosquito egg rafts than the control (P 〈 0.01) whereas for the (5S,6R)- enantiomer (IIa) there was no statistically significant oviposition attraction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00988573
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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    Artikel (Nationallizenzen)
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