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  • Column liquid chromatography  (2)
  • Abducens internuclear interneuron  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Inhibitory connections of nystagmus-related reticular burst neurons with neurons in the abducens, prepositus hypoglossi and vestibular nuclei in the cat (1980)
    Springer
    Experimental brain research 39 (1980), S. 301-311 
    Details
    ISSN: 1432-1106
    Schlagwort(e): Inhibitory burst neuron ; Reticular formation ; Abducens internuclear interneuron ; Prepositus hypoglossi neuron ; Vestibular neuron
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Action potentials of inhibitory burst neurons (IBNs) were extracellularly recorded in the pontomedullary reticular formation in the cat. These neurons were identified by their burst activity coincident with the quick inhibitory phase of the contralateral abducens nerve during vestibular nystagmus and by their antidromic activation from the contralateral abducens nucleus. During extracellular recording from the soma of single IBNs, another electrode for microstimulation was systematically tracked throughout the brain stem. For each IBN investigated, the effective sites for antidromic activation were invariably found in the contralateral abducens, prepositus hypoglossi, medial vestibular nuclei and the area ventral to the prepositus hypoglossi nucleus. Stimulation of neither the ipsilateral brain stem nor the oculomotor nuclei evoked antidromic responses in IBNs. Extracellular spikes of single IBNs and neurons in the overlying projection area were recorded simultaneously. Their correlation was examined by using peri-spike time histograms. Shortly after the spikes of single IBNs, the activity of motoneurons and internuclear interneurons in the abducens nucleus, and of type II neurons in the prepositus hypoglossi and vestibular nuclei, was depressed. Connections of IBNs with ipsilateral medial rectus motoneurons were studied by spike-triggered averaging of membrane potentials of the motoneurons and action potentials of the medial rectus nerve. Single IBN spikes induced a di- or polysynaptic disfacilitation in the motoneurons. This disfacilitation was concluded to be mediated by some of the above-described interneurons which were directly inhibited by IBNs. Their depressant effect on medial rectus motoneuronal spike activity was comparable to that on the spike activity of contralateral abducens motoneurons.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00237119
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  • 2
    Digitale Medien
    Digitale Medien
    Isolation of new quinidine metabolites and simultaneous determination of quinidine and its metabolites in blood and urine by direct injection HPLC analysis (1985)
    Springer
    Chromatographia 20 (1985), S. 671-676 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; Direct injection of biological samples ; New quinitidine metabolites ; Deproteinisation on precolumn ; Column switching
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary New quinidine metabolites, including 10,11-dihydrodiol quinidine N-oxide, 10,11-dihydrodiol quinidine and their glucuronides, were found in human urine. A quinidine monitoring HPLC method including these metabolites, is proposed by the direct injection of body fluid samples onto the precolumn for deproteinization followed by reverse phase separation in the analytical column with a column switching technique. The recovery of spiked quinidine and its metabolites in plasma was quantitative (98–102%) with good reproducibility (C.V.: 1.6–4.0%). Several clinical samples such as whole blood and urine were analyzed by the present method.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02262689
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  • 3
    Digitale Medien
    Digitale Medien
    On-line deproteinization of serum sample for HPLC analysis of hydrophilic compounds and its application to gentamicin (1986)
    Springer
    Chromatographia 21 (1986), S. 519-522 
    Details
    ISSN: 1612-1112
    Schlagwort(e): Column liquid chromatography ; On-line deproteinization ; Butyl Toyopearl 650-M ; Gentamicin in serum
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Summary The binding of serum proteins with Butyl Toyopearl (BT) 650-M has been investigated and applied to on-line deproteinization for the HPLC determination of gentamicin components, c1, c1a, c2, in serum. It was found that in 0.4% perchloric acid medium about 36mg of BSA was adsorbed on 1ml of wet gel. Under this condition hydrophilic components such as gentamicin passed through the pre-column packed with BT 650-M, while serum proteins and hydrophobic components were trapped in the pre-column. The ion pair between gentamicin components and pantanesulfonate anion was effectively trapped in a reversed-phase analytical column. It was then eluted and fluorometrically determined by post-column derivatization with o-phthalaldehyde. The recovery was quantitative with good reproducibility at therapeutic concentrations in sera. Several clinical samples were analyzed by the method.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02310539
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