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rCBF abnormalities detected, and sequentially followed, by SPECT in neuro-Behcet's syndrome with normal CT and MRI imaging (1992)

Markus, H. S. ; Bunker, C. B. ; Kouris, K. ; [et al.]

Springer

Journal of neurology 239 (1992), S. 363-366

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ISSN: 1432-1459

Keywords: Regional cerebral blood flow ; Neuro-Behcet's syndrome ; Computed tomography ; Magnetic resonance imaging ; Single photon emission tomography

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Conventional imaging with computed tomography (CT) and magnetic resonance imaging (MRI) may show abnormalities in central nervous system Behcet's syndrome but is normal in some cases. Recently in two cases positron emission tomography has shown abnormalities in blood flow and glucose metabolism far more extensive than the abnormalities seen on CT and MRI scans in the same patients. We report a patient with neuro-Behcet's syndrome presenting with headache and personality change in whom CT and MRI brain imaging was normal, but regional cerebral blood flow imaging using single photon emission tomography with the tracer HMPAO showed extensive perfusion deficits which partially reversed after 3 months of prednisolone therapy. This technique may aid the diagnosis of cerebral involvement in Behcet's syndrome, although the cause and incidence of the perfusion deficits need further evaluation.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00812151

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Capillary ion analysis of potassium concentrations in human vitreous humor (1998)

Ferslew, Kenneth E. ; Hagardorn, Andrea N. ; Harrison, M. Travis ; [et al.]

Weinheim : Wiley-Blackwell

Electrophoresis 19 (1998), S. 6-10

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ISSN: 0173-0835

Keywords: Capillary electrophoresis ; Vitreous humor ; Potassium ; Chemistry ; Biochemistry and Biotechnology

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Capillary ion analysis (CIA) is a form of capillary electrophoresis which uses the differential electrophoretic mobility of ions to perform a separation of an ionic mixture. Application of this technique for direct detection of potassium concentrations in human vitreous humor was the purpose of this investigation. CIA was performed using a Waters Quanta 4000 Capillary Electrophoresis System with a 745 Data Module using a 75 μm × 60 cm capillary and a run electrolyte of 67.7 mg hydroxyisobutyric acid (HIBA), 52.8 mg 18-crown-6 ether and 64 μL UV-CAT-1 reagent (4-ethylbenzylamine) in a volume of 100 mL water (18 Mohm) with a voltage of 20 kV using ultraviolet absorption detection at 214 nm. Migration times were: ammonium ion, 2.86 min; potassium, 3.24 min; calcium, 3.84 min; sodium, 3.98 min; barium (internal standard), 4.68 min; and lithium, 4.79 min. Correlation coefficients (r) between peak area ratios and concentration ranges of 2.5-144 mmole/L (100-1000 ppm) were from 0.9855 to 0.9999. Coefficients of variation (CV) ranged from 1.45 to 13.8% between days and from 1.38 to 9.43% within-day. Application of this methodology to twenty-five vitreous humor specimens from forensic cases was compared to analysis by ion-specific electrode for potassium concentration. Comparison of CIA to ion-specific electrode analysis of vitreous humor potassium concentrations revealed a correlation coefficient of 0.9642. CIA is applicable to forensic analysis of potassium concentration in forensic vitreous humor specimens. Quantitation of numerous cation concentrations is possible by direct CIA of vitreous humor.

Additional Material: 4 Ill.