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  • 1
    Electronic Resource
    Electronic Resource
    Excitative effects in anaesthetized rabbits from subarachnoidally injected iso- and hyperosmolar solutions of iohexol and metrizamide (1984)
    Springer
    Neuroradiology 26 (1984), S. 131-136 
    Details
    ISSN: 1432-1920
    Keywords: Contrast media ; neurotoxicity ; chemotoxicity ; osmolality ; subarachnoid injection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Equimolar doses of iohexol and metrizamide (0.48 mmol/kg body weight = 185 mg I/kg), administered in solutions iso- and hyperosmolar to the CSF, were injected subarachnoidally into rabbits under pentobarbital anaesthesia. No excitative effects of iohexol were observed in the behaviour of the rabbits during a 3-h period immediately after the injection. Metrizamide caused significant, severe excitative effects, ranging from hyperexcitability to repeated generalized seizures. The frequency and severity of excitative effects were independent of the osmolality of the metrizamide solutions injected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00339861
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Sex and age related differences in postmyelographic adverse reactions (1989)
    Springer
    Neuroradiology 31 (1989), S. 331-335 
    Details
    ISSN: 1432-1920
    Keywords: Myelography ; Adverse reactions ; Sex differences ; Contrast media ; Metrizamide ; Iohexol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Differences in frequency of postmyelographic adverse reactions were analyzed with respect to sex and age in a prospective study including 1026 patients injected with metrizamide and 739 injected with iohexol. Regardless of the type of contrast medium or myelography, all types of adverse reactions were 1.4–3.8 times as frequent in women as in men. Most of the differences were statistically significant. Headache was more frequent, while vomiting and dizziness were less frequent in both women and men aged 26–50 years compared with those over 50 years of age. Dizziness and increased low back pain were consistently reported spontaneously by the patients less frequently than emerged via formal interview. The large differences between the sexes suggest that further research on contrast media toxicity would be best performed with separation of the data by gender.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00344177
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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