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  • 1
    Digitale Medien
    Digitale Medien
    Effects of brofaremine (CGP 11 305A), a short-acting, reversible, and selective inhibitor of MAO-A on sleep, nocturnal penile tumescence and nocturnal hormonal secretion in three healthy volunteers (1987)
    Springer
    Psychopharmacology 92 (1987), S. 110-114 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Brofaremine ; Sleep ; Nocturnal penile tumescence ; Cortisol ; Human growth hormone ; Prolactin ; Testosterone ; LH ; FSH
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effects of brofaremine (CGP 11 305A), a short-acting, reversible and selective inhibitor of MAO-A, on sleep, nocturnal penile tumescence (NPT) and hormonal secretion during the night were studied during a long-term trial. Three healthy males underwent sleep-EEG and NPT recordings during consecutive nights (1) under placebo, (2) under stepwise increasing dosages of brofaremine and (3) under placebo after withdrawal. Hormone profiles were sampled during selected nights to analyze the plasma concentration of cortisol, HGH, prolactin, testosterone, LH and FSH. REM sleep was suppressed markedly under 150 mg brofaremine, while stages 1 and 2 increased. In comparison to the effect of irreversible MAOIs the REM suppression was shorter and did not persist after withdrawal. A decrease of the plasma concentration of the drug coincided with a return of sleep variables to baseline values. A REM rebound occurred after withdrawal of brofaremine. REM sleep and NPT showed a dissociation; NPT variables did not follow the decrease of REM sleep. The effects of REM parameters are correlated with the dosage and the plasma concentration of the substance. Intraindividually, a decrease in secretion of HGH was observed throughout the trial. No marked changes were found in the other endocrinological variables.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00215489
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  • 2
    Digitale Medien
    Digitale Medien
    Sleep EEG and nocturnal secretion of cortisol and growth hormone in male patients with endogenous depression before treatment and after recovery
    Amsterdam : Elsevier
    Journal of Affective Disorders 16 (1989), S. 189-195 
    Details
    ISSN: 0165-0327
    Schlagwort(e): Cortisol ; Endogenous depression ; Growth hormone ; Sleep EEG ; Sleep endocrinology
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Medizin , Psychologie
    Materialart: Digitale Medien
    URL: http://linkinghub.elsevier.com/retrieve/pii/0165-0327(89)90073-6
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  • 3
    Digitale Medien
    Digitale Medien
    Bretazenil modulates sleep EEG and nocturnal hormone secretion in normal men (1995)
    Springer
    Psychopharmacology 122 (1995), S. 115-121 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Bretazenil ; Sleep EEG ; Cortisol ; Growth hormone ; Prolactin ; GABA benzodiazepine receptor ; EEG power spectra
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Preclinical data suggest that the imidazo-diazepinone derivative bretazenil (Ro 16-6028) has anxiolytic and anticonvulsant properties with only weak sedative effects. We examined the influence of oral administration of 1 mg bretazenil on the sleep EEG and the concomitant nocturnal secretion of cortisol, growth hormone and prolactin in ten healthy young men. After bretazenil we found a significant increase in stage 2 sleep and a significant reduction in stage 3 sleep. REM latency was prolonged. Spectral analysis of sleep-EEG power revealed a decrease in delta and in theta power and an increase in sigma power. We found no significant influence on sleep onset latency or on intermittent wakefulness. Bretazenil prompted a significant decrease in cortisol secretion and a significant increase in prolactin release. It had no major influence on growth hormone secretion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02246085
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  • 4
    Digitale Medien
    Digitale Medien
    Flumazenil exerts intrinsic activity on sleep EEG and nocturnal hormone secretion in normal controls (1994)
    Springer
    Psychopharmacology 113 (1994), S. 334-338 
    Details
    ISSN: 1432-2072
    Schlagwort(e): Sleep EEG ; Cortisol ; Growth hormone ; Flumazenil ; Midazolam
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The physiological function of benzodiazepine (BDZ) receptors includes regulation of sleep and neuroendocrine activity. Most of the pharmacological effects of BDZ are blocked by flumazenil. However, recent neurological and behavioral studies suggest that flumazenil has its own central intrinsic activity. This issue was addressed in a study of the sleep EEG and the nocturnal secretion of growth hormone and cortisol in ten normal male controls, who were given flumazenil either alone or in combination with the BDZ agonist midazolam, placebo and midazolam alone. Flumazenil prompted an increase in sleep onset latency, a decrease in slow wave sleep and an increase in wakefulness. Plasma cortisol concentrations after flumazenil administration were lower than after midazolam. Both flumazenil and midazolam decreased nocturnal growth hormone secretion. After simultaneous application of both BDZ receptor ligands the growth hormone blunting was amplified. Our study demonstrates that at the level of the sleep EEG and neuroendocrine activity flumazenil is capable of exerting both agonistic and inverse agonistic or antagonistic effects.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02245206
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  • 5
    Digitale Medien
    Digitale Medien
    Abhängigkeit von „Non- Benzodiazepinhypnotika”Zwei Fallberichte (1999)
    Springer
    Der Nervenarzt 70 (1999), S. 72-75 
    Details
    ISSN: 1433-0407
    Schlagwort(e): Schlüsselwörter Zopiclon ; Zolpidem ; Mißbrauch ; Abhängigkeit ; Absetzsymptomatik ; Key words Zopiclone ; Zolpidem ; Abuse ; Dependence ; Withdrawal
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Summary With the introduction of the non-benzodiazepine hypnotics zopiclone and zolpidem it was expected to have hypnotics without side effects and risks characteristically seen with benzodiazepines. We report two cases with high-dose usage and dependency of non-benzodiazepine hypnotics. Both patients were prescribed the drugs to treat sleep disturbances occuring during a depressive episode. While one patient had a polysubstance abuse there was no evidence for an abuse history in the other patient. To reduce withdrawal symptoms long-acting benzodiazepines were given to both patients. Thus, it seems that not only patients with a history of substance abuse but also patients with a psychiatric disorder are at risk for abuse of non-benzodiazepine hypnotics. Considering the increasing number of case reports with abuse and dependence of zopiclone and zolpidem it seems necessary to reevaluate the dependency risk of the currently available non-benzodiazepine hypnotics.
    Notizen: Zusammenfassung Mit der Einführung der „Non-Benzodiazepinhypnotika” Zolpidem und Zopiclon war die Hoffnung verbunden, Hypnotika ohne benzodiazepintypische Nebenwirkungen und Gefahren zur Verfügung zu haben. Wir stellen 2 Kasuistiken mit hochdosierter Einnahme von und Abhängigkeitsentwicklung unter „Non-Benzodiazepinhypnotika” vor. Bei beiden Patienten begann die Substanzeinnahme aufgrund von Schlafstörungen i.R. eines depressiven Syndroms. Während bei dem einen Patient eine Polytoxikomanie bestand, fanden sich bei dem anderen keine Hinweise für einen Mißbrauch anderer psychoaktiver Substanzen oder einen Mißbrauch in der Vorgeschichte. Zur Abmilderung der Absetzsymtomatik erfolgte eine Umstellung auf langwirksame Benzodiazepine und eine stufenweise Reduktion derselben. Neben Patienten mit Mißbrauch oder Abhängigkeit in der Vorgeschichte scheinen auch Patienten mit depressiven Störungen gefährdet zu sein, Zopiclon oder Zolpidem mißbräuchlich einzunehmen. Das potentielle Abhängigkeitsrisiko der „Non-Benzodiazepinhypnotika” muß daher auch in der klinischen Praxis beachtet werden.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001150050403
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