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  • 1
    Electronic Resource
    Electronic Resource
    Relation between leukocyte counts and cortisol secretion in CML patients undergoing combined TNF α/IFN α therapy (1992)
    Springer
    Annals of hematology 65 (1992), S. 116-120 
    Details
    ISSN: 1432-0584
    Keywords: TNF α ; IFN α-2b ; Leukocytes ; Cortisol ; ACTH ; CML
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary During long-term interferon α-2b (IFN) therapy of Philadelphia chromosome-positive chronic myelogenous leukemia (CML) patients, short-term effects of tumor necrosis factor α (TNF) on peripheral leukocyte counts, as well as cortisol and corticotropin (ACTH) release were studied. TNF (40–160μg/m2) was given as a 2-h infusion on 5 consecutive days every 3 weeks, in addition to s.c. daily IFN injections (4 mio U/m2), to four (two male/two female) patients, who had been treated for more than 8 months with IFN and additionally for 0–7 months with TNF. Leukocyte counts, cortisol, and ACTH were determined at 30-min intervals between 4 p.m. and midnight. Profiles were determined the day before and on day 1 of TNF therapy. Leukocyte numbers decreased 30 min after start of TNF administration and increased 30–60 min later with a rebound until the next TNF application. The increase of leukocyte counts was due mostly to neutrophil granulocytes. ACTH levels increased 30 min, cortisol 60 min, and leukocyte counts 90 min after start of TNF infusion. Metopirone, an inhibitor of cortisol synthesis given to one patient, suppressed the TNF-induced stimulation of cortisol secretion and subsequent increase of leukocyte counts, while ACTH blood levels were enhanced. It was concluded that leukocyte count increases after TNF/IFN administration might be related to TNF-evoked cortisol secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01695809
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  • 2
    Electronic Resource
    Electronic Resource
    Age-dependency of alpha- and beta-adrenoceptors on thrombocytes and lymphocytes of asthmatic and nonasthmatic children (1984)
    Springer
    European journal of pediatrics 142 (1984), S. 111-116 
    Details
    ISSN: 1432-1076
    Keywords: Bronchial asthama ; Adrenergic theory ; α- and β-adrenoceptors ; Blood cells ; Age-dependent maturation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Among the possible mechanisms which may cause wheezing or asthmatic episodes a genetically determined β-adrenoceptor blockade and a hyperresponsiveness of α-andrenoceptors has been postulated. Evidence to support this hypothesis stems from an increased bronchial sensitivity to β-blockers, a reduced formation of cyclic AMP in response to β-adrenergic stimulation and enhanced α-adrenergic responses in asthmatic subjects. The recent development of techniques for measuring the specific, high-affinity binding of radiolabeled α-and β-adrenergic antagonists made it possible to study α- and β-adrenoceptors in vitro. Based upon the assumption that a change in the number and/or affinity of adrenergic receptors might be a general phenomenon, we have performed α- and β-receptor binding studies on lymphocytes and platelets from wheezing infants and asthmatic children as well as of infants, children, and adults not suffering from these diseases. Using 125[I]-cyanopindolol (ICYP) and 3[H]-yohimbine (HYOH) as highly specific ligands for α- and β-adrenoceptors, the following results were obtained: (1) Lymphocytes and platelets from control subjects and asthamatics bound similar amounts of ICYP and HYOH and thus showed no differences either in the number or the affinity of α- and β-adrenoceptors. Lymphocytes and platelets of wheezing and nonwheezing infants also bound the same amounts of the radioligands. (2) In asthmatic children receiving 4×2 puffs salbutamol β-adrenoceptor were down-regulated and this may mimic β-adrenoceptor blockade. (3) When subjects were divided into four categories according to age (0–5, 5–10, 10–20 years, adults) the number of β-adrenoceptor binding sites showed an age-dependent increase. The number and affinity of α-adreneceptor binding sites on platelets was neither influenced by age nor disease. It is concluded that the α- and β-adrenoceptors of wheezing infants and asthmatic children at least on blood cells are normal. However the β-adrenoceptors show an age-dependent maturation process, which may account for an unresponsiveness to β-adrenoceptor agonists in wheezing infants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445589
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    Paper (German National Licenses)
    Fulltext
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