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Cyclosporin A versus methotrexate, followed by rescue with folinic acid as prophylaxis of acute graft-versus-host disease after bone marrow transplantation (1989)

Torres, A. ; Martinez, F. ; Gomez, P. ; [weitere]

Springer

Annals of hematology 58 (1989), S. 63-68

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ISSN: 1432-0584

Schlagwort(e): Prophylaxis for acute GVHD ; Cyclosporin A ; MTX + folinic acid

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary Fifty-seven patients undergoing bone marrow transplantation were randomly assigned to receive either cyclosporin A (CsA, n=26) or methotrexate, followed by rescue with folinic acid (MTX + FA, n=31) as prophylaxis for graft-versus-host disease (GVHD). All patients but one receiving CsA had evidence of sustained engraftment, and there was no difference between the two groups on the day in which marrow engraftment was documented. Oropharyngeal mucositis was of similar incidence and severity in the two groups. In contrast, patients receiving CsA showed higher renal and hepatic toxicity rates than those treated with MTX + FA. Severe-to-moderate acute GVHD (grades II–IV) was documented in 12 patients receiving CsA and in 12 treated with MTX + FA. The cumulative incidence of this complication was similar in both groups (46.1% and 38.7%). Similarly, there was no difference in the incidence of chronic GVHD. The leukemic relapse rates were also comparable, as well as the estimated probability of survival, which was 55% in patients treated with MTX + FA and 41% in those who were given CsA. We conclude that MTX + FA is as effective as CsA in the prevention of GVHD, with the additional advantage of reduced renal and hepatic toxicities.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00320650

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Digitale Medien

Photometric determination of molybdenum in iron and steels using tin(II) chloride in nonaqueous solvent (1973)

Bermejo-Martínez, F. ; Latas-Pérez, P.

Springer

Fresenius' Zeitschrift für analytische Chemie 264 (1973), S. 139-142

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ISSN: 1618-2650

Schlagwort(e): Best. von Molybdän in Eisen, Stahl ; Śpektralphotometrie ; Zinn(II)-chlorid als Reduktionsmittel, Thiocyanatkomplex

Quelle: Springer Online Journal Archives 1860-2000

Thema: Chemie und Pharmazie

Beschreibung / Inhaltsverzeichnis: Summary A new procedure is proposed for the photometric determination of molybdenum in iron and steels using thiocyanate and tin(II) chloride solution [in glycerol-ethannol (3∶1) or in diethylenglycol] as a reducer and extraction with n-butyl acetate. Beer's law is obeyed between 0.2 and 80 μg Mo/ml. The minimum photometric error is 3.2%, the molar absorptivity is 15640 at 470 nm and the best concentration range for determination is between 0.6 and 6 μg Mo/ml.

Notizen: Zusammenfassung Das vorgeschlagene Verfahren beruht auf Bildung des Thiocyanatkomplexes unter Verwendung von Zinn(II)-chlorid als Reduktionsmittel [in Glycerin/Äthanol (3∶1) oder Diäthylenglykol]. Als Extraktionsmittel dient n-Butylacetat. Das Beersche Gesetz wird im Bereich 0,2–80 μg Mo/l befolgt. Der kleinste photometrische Fehler beträgt 3,2%, die molare Extinktion 15640 bei 470 nm und der optimale Konzentrationsbereich 0,6–6 μgMo/l.