ISSN:
1432-1440
Keywords:
Diabetes mellitus
;
Cyclosporine
;
Toxicity
;
Risk factors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Renal biopsy specimens of 40 patients with recent-onset insulin-dependent diabetes mellitus treated with cyclosporine (CSA) for 6–29 months were examined. Cyclosporine-associated chronic vascular interstitial toxicity of moderate intensity was found in 10 patients (25%). The most prominent lesions were interstitial fibrosis and tubular atrophy. Arteriolopathy was less pronounced and glomerular damage unremarkable. A significant correlation exists between the extent of tubular atrophy and CSA trough whole blood levels. These data indicate that the development of CSA-associated chronic nephropathy is dose-dependent.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02115783
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