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  • 1
    Digitale Medien
    Digitale Medien
    Contribution of immunophenotypic and genotypic analyses to the diagnosis of acute leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 13-27 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Acute leukemia ; Diagnosis ; Immunophenotypic ; Cytogenetics ; Molecular genetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Diagnostic accuracy in acute leukemia (AL) can be improved if traditional morphology and cytochemistry are supplemented with immunophenotypic and genotypic analyses. This multiparameter approach is of crucial importance for the management of patients, as it enables the identification of leukemic syndromes with distinct biological features and response to treatment. Immunophenotyping using monoclonal antibodies has been universally accepted as a useful adjunct to morphological criteria. This technique is particularly valuable in diagnosing and subclassifying acute lymphoblastic leukemia and is also essential in certain types of acute myeloid leukemia (AML), such as AML with minimal differentiation or acute megakaryoblastic leukemia. Cytogenetic findings can be quite helpful in establishing the correct diagnosis and can add information of prognostic significance. A number of specific chromosomal abnormalities have been recognized that are very closely, and sometimes uniquely, associated with morphologically and clinically distinct subsets of leukemia. An even more basic understanding of normal and malignant hematopoietic cells has begun to evolve as molecular biology begins to unravel gene misprogramming by Southern and Northern blot analysis, the polymerase chain reaction, and fluorescence in situ hybridization. With the extensive use of these techniques it has become apparent that a proportion of leukemias exhibit the biologically relevant molecular defect in the absence of a karyotypic equivalent. On the other hand, apparently uniform chromosomal abnormalities such as the t(1;19) (q23;p13), t(9;22) (q33;q11), t(8;14) (q24;q32), or t(15;17) (q21;q21) may differ at the molecular level. Data collected from these modern technologies have introduced a greater complexity, which needs to be taken into consideration to improve both the diagnostic precision and the reproducibility of current classifications.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01696228
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  • 2
    Digitale Medien
    Digitale Medien
    Contribution of immunophenotypic and genotypic analyses to the diagnosis of acute leukemia (1995)
    Springer
    Annals of hematology 71 (1995), S. 13-27 
    Details
    ISSN: 1432-0584
    Schlagwort(e): Key words Acute leukemia ; Diagnosis ; Immunophenotypic ; Cytogenetics ; Molecular genetics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract  Diagnostic accuracy in acute leukemia (AL) can be improved if traditional morphology and cytochemistry are supplemented with immunophenotypic and genotypic analyses. This multiparameter approach is of crucial importance for the management of patients, as it enables the identification of leukemic syndromes with distinct biological features and response to treatment. Immunophenotyping using monoclonal antibodies has been universally accepted as a useful adjunct to morphological criteria. This technique is particularly valuable in diagnosing and subclassifying acute lymphoblastic leukemia and is also essential in certain types of acute myeloid leukemia (AML), such as AML with minimal differentiation or acute megakaryoblastic leukemia. Cytogenetic findings can be quite helpful in establishing the correct diagnosis and can add information of prognostic significance. A number of specific chromosomal abnormalities have been recognized that are very closely, and sometimes uniquely, associated with morphologically and clinically distinct subsets of leukemia. An even more basic understanding of normal and malignant hematopoietic cells has begun to evolve as molecular biology begins to unravel gene misprogramming by Southern and Northern blot analysis, the polymerase chain reaction, and fluorescence in situ hybridization. With the extensive use of these techniques it has become apparent that a proportion of leukemias exhibit the biologically relevant molecular defect in the absence of a karyotypic equivalent. On the other hand, apparently uniform chromosomal abnormalities such as the t(1;19) (q23;p13), t(9;22) (q33;q11), t(8;14) (q24;q32), or t(15;17) (q21;q21) may differ at the molecular level. Data collected from these modern technologies have introduced a greater complexity, which needs to be taken into consideration to improve both the diagnostic precision and the reproducibility of current classifications.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01696228
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  • 3
    Digitale Medien
    Digitale Medien
    On the construction and numerical solution of transmission-line and lumped network models of Maxwell's equations (1980)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 15 (1980), S. 13-30 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: It is sometimes convenient to express a numerical algorithm in terms of a network model. The physical picture given can often help the engineer to visualize the properties of the method. In field problems, a lumped network model corresponds to a space discrete field while a transmission-line model corresponds to a field which is discrete in space and time. In this paper, the relationship is given between the lumped network models and transmission-line network models used in the steady-state solution of Maxwell's equations in two and three space dimensions. The use of dual networks is also discussed. An analysis is given for the velocity of waves travelling in any direction across the networks and this is used to compare the accuracy of the models. The use of diakoptics or substructures for the solution of large networks is outlined and this is illustrated by a compound two-dimensional example.
    Zusätzliches Material: 10 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620150103
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  • 4
    Digitale Medien
    Digitale Medien
    Stable and time-dissipative finite element methods for the incompressible Navier-Stokes equations in advection dominated flows (1995)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 38 (1995), S. 1475-1506 
    Details
    ISSN: 0029-5981
    Schlagwort(e): finite elements ; incompressible Navier-Stokes ; upwinding schemes ; Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: This paper examines a new Galerkin method with scaled bubble functions which replicates the exact artificial diffusion methods in the case of 1-D scalar advection-diffusion and that leads to non-oscillatory solutions as the streamline upwinding algorithms for 2-D scalar advection-diffusion and incompressible Navier-Stokes. This method retains the satisfaction of the Babuska-Brezzi condition and, thus, leads to optimal performance in the incompressible limit. This method, when, combined with the recently proposed linear unconditionally stable algorithms of Simo and Armero (1993), yields a method for solution of the incompressible Navier-Stokes equations ideal for either diffusive or advection-dominated flows. Examples from scalar advection-diffusion and the solution of the incompressible Navier-Stokes equations are presented.
    Zusätzliches Material: 24 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620380904
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  • 5
    Digitale Medien
    Digitale Medien
    Modelling flow over a backward-facing step using the F.E.M. and the two-equation model of turbulence (1981)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 1 (1981), S. 295-304 
    Details
    ISSN: 0271-2091
    Schlagwort(e): Numerical Methods ; Turbulence ; Separation ; Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Notizen: Flow over a downstream-facing step is predicted using the F.E.M. A two-equation model of turbulence is employed where the transport of turbulence kinetic energy and dissipation rate are depicted using transport-type equations, i.e. the two-equation model of turbulence. The results obtained are compared with other models and experimental results. Generally, the model was found to be under-predictive with regard to the reattachment length when previous empirical data was used in the transport equations.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/fld.1650010403
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  • 6
    Digitale Medien
    Digitale Medien
    Turbulent heat transfer via the F.E.M.: Heat transfer in rod bundles (1983)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 3 (1983), S. 363-375 
    Details
    ISSN: 0271-2091
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Notizen: Heat transfer associated with forced convection between bundles of cylindrical fuel rods is analysed using the finite element method. A subchannel technique is employed and the numerical results are compared with previous experimental and numerical values. The solid and fluid zones are analysed, for temperature distribution, as a single domain.
    Zusätzliches Material: 14 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/fld.1650030406
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  • 7
    Digitale Medien
    Digitale Medien
    Editorial (1994)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 19 (1994), S. iii 
    Details
    ISSN: 0271-2091
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/fld.1650190702
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  • 8
    Digitale Medien
    Digitale Medien
    Editorial (1994)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 19 (1994), S. i 
    Details
    ISSN: 0271-2091
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/fld.1650190810
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  • 9
    Digitale Medien
    Digitale Medien
    Editorial (1994)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 19 (1994), S. i 
    Details
    ISSN: 0271-2091
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/fld.1650190910
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  • 10
    Digitale Medien
    Digitale Medien
    Editorial (1994)
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 19 (1994), S. i 
    Details
    ISSN: 0271-2091
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Maschinenbau
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/fld.1650191008
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