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  • DNA damage  (1)
  • Epstein-Barr virus  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Urinary excretion of mutagens and covalent DNA damage induced in the bladder and kidney after passive smoking in rats (1994)
    Springer
    Urological research 22 (1994), S. 93-97 
    Details
    ISSN: 1434-0879
    Schlagwort(e): Passive smoking ; DNA damage ; Bladder ; Kidney ; 32P-postlabeling assay ; Urine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Using 32P-postlabeling assay, we studied the effect of sidestream smoke of cigarettes, so-called passive smoking, on the covalent DNA adduct formation in an animal model. Urine samples of 18 rats, 9 male and 9 female, before smoking resulted in an average of 2.4 adducts per 1×107 nucleotides per 24-h urine of a rat in the target plasmid DNA after incubation for 2 h in vitro. Urine samples of 4 out of 6 rats after exposure to sidestream smoke induced additional adducts in the target DNA. The incidence increased to 17.5 adducts per 1×107 nucleotides per 24-h urine of a rat. Without exposure to smoke, no increase in the adduct formation was observed. Adduct formations similar to those induced in vitro were detected in the bladder and kidney DNA, but not in the testicular DNA, of the four rats exposed to sidestream smoke. These observations suggest that passive smoking causes covalent DNA damage of the cells in the bladder and kidney by excreting chemicals in urine. Passive smoking as well as active smoking might contribute to the bladder and renal carcinogenic process.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00310998
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Enhanced expression of Epstein-Barr virus early antigens by antitubulin agents in a latently infected human lymphoblastoid cell line (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 372-373 
    Details
    ISSN: 1420-9071
    Schlagwort(e): Epstein-Barr virus ; tumor promoter ; antitubulin agents ; vinblastine ; vincristine ; anticancer agents
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary 28 anticancer agents have been surveyed for Epstein-Barr virus (EBV) activating potency. Two vinca alkaloids with antitubulin activity, vinblastine (VLB) and vincristine (VCR), enhanced the expression of EBV early antigens (EA) in a latently infected human lymphoblastoid cell line (Raji), when used in combination withn-butyrate. Other antitubulin agents, colchicine, colcemid, and podophyllotoxin, had the same effect, although their effects were less than that of the potent tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02004511
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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