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  • 1
    Electronic Resource
    Electronic Resource
    Effects of coenzymeQ10 administration on pulmonary function and exercise performance in patients with chronic lung diseases (1993)
    Springer
    Journal of molecular medicine 71 (1993), S. S162 
    Details
    ISSN: 1432-1440
    Keywords: CoenzymeQ10 ; Chronic obstructive pulmonary disease ; Hypoxemia ; Exercise performance ; Blood lactate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Serum coenzyme Q10 (CoQ10) levels were measured at rest and during incremental exercise in 21 patients with chronic obstructive pulmonary disease (COPD) and 9 patients with idiopathic pulmonary fibrosis (IPF). The mean serum CoQ10 levels at rest in patients with COPD and IPF were 0.56 ± 0.20 and 0.45 ± 0.16 μg/ml, respectively. In both groups these levels were decreased compared with those of healthy subjects. In the patients with COPD, CoQ10 levels were significantly correlated with body weight, however, there was no correlation between CoQ10 levels and ventilatory function, PaO2, VO2/kg at rest, or maximal VO2. In eight of nine patients whose PaO2 at rest was lower than 75 torr, serum CoQ10 levels were lower than 0.5 μg/ml. We studied the effects of the oral administration of CoQ10 at 90 mg/day for 8 weeks on pulmonary function and exercise performance in eight patients with COPD. Serum CoQ10 levels were significantly elevated in association with an improvement in hypoxemia at rest, whereas pulmonary function was unaltered. Oxygen consumption during exercise was not changed, whereas PaO2 was significantly improved, and heart rate was significantly decreased compared with the results obtained at an identical workload at baseline. Furthermore, lactate production was suppressed during the anaerobic exercise stage after CoQ10 administration, and exercise performance tended to increase. These data suggested that CoQ10 has favorable effects on musclar energy metabolism in patients with chronic lung diseases who have hypoxemia at rest and/or during exercise.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00226860
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  • 2
    Electronic Resource
    Electronic Resource
    ATP synthesis associated with the conversion of hexachlorocyclohexane related compounds (1982)
    Springer
    Archives of microbiology 131 (1982), S. 330-333 
    Details
    ISSN: 1432-072X
    Keywords: Chlostridium rectum ; Chlorobenzene ; HCH conversion ; Stickland reaction ; ATP synthesis ; Dechlorination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Clostridium rectum strain S-17 converts γ-1,2,3,4,5,6-hexachlorocyclohexane (HCH) related compounds to chlorobenzenes. The metabolites from γ-1,2,3,4,5,6-hexachlorocyclohexene and γ-1,3,4,5,6-pentachlorocyclohexene are identified as 1,2,4-trichlorobenzene and 1,4-dichlorobenzene, respectively. ATP synthesis, converting these chlorinated compounds, is observed in the cell suspension of C. rectum as indicated by luciferase-luciferin reaction and phosphorylation of 32P-labeled phosphate. These observation lead to the conclusion that HCH and related compounds serve as artificial electron acceptors of the Stickland reaction, and therefore, the reductive dechlorination is associated with ATP synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00411180
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    Paper (German National Licenses)
    Fulltext
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