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  • 1
    Electronic Resource
    Electronic Resource
    Transfer of sodium and water through isolated rat colonic mucosa under the influence of deoxycholate and oxyphenisatin (1977)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 297 (1977), S. 185-190 
    Details
    ISSN: 1432-1912
    Keywords: Isolated rat colon ; Sodium transfer ; Water transfer ; Oxyphenisatin ; Deoxycholate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The influence of oxyphenisatin (OP), a diphenolic laxative, and deoxycholate (DC) on the transfer of sodium and water in an everted sac preparation of stripped rat colon was investigated. 2. OP (10−5 M, mucosal side) and DC (3×10−4 M, mucosal side) completely blocked net water and sodium absorption. Net movements from the serosal to the mucosal side could not be induced by higher concentrations of the drugs. 3. Unidirectional sodium movements in both directions were increased by OP and DC. 4. The effect of DC on the sodium flux from the serosal to the mucosal side was reversible. 5. The potassium content of the mucosal epithelium was not changed by DC and OP. 6. The integrity of the epithelium, as judged by light microscopy, was not disturbed by either drug under the experimental conditions. 7. It is concluded that DC and OP do not interfere with active transport mechanisms but increase the permeability of the epithelium to sodium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00499929
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Pathway of sodium moving from blood to intestinal lumen under the influence of oxyphenisatin and deoxycholate (1976)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 293 (1976), S. 31-37 
    Details
    ISSN: 1432-1912
    Keywords: Colonic mucosa ; Oxyphenisatin ; Deoxycholate ; Sodium ; Intercellular pathway
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The transfer of 51CrEDTA and inulinsubstances which are distributed only in the extracellular space-across the rat colonic mucosa in vivo is increased by oxyphenisatin O (3.5 · 10−5 M) and deoxycholate D (3 · 10−3 M). 2. O and D do not change the size of the intra- and extracellular fluid compartments of the mucosa as measured with 51CrEDTA from the blood side. The sodium and potassium content of the mucosal tissue is not altered. Therefore the calculated intracellular concentrations of sodium and potassium remain constant. 3. The time course of the 22Na uptake into the mucosal epithelium is not influenced by O and D up to 5 min after i.v. injection. The specific activity of sodium, however, in the luminal fluid increases under the influence of O (twofold) and D (fivefold). The uptake of 22Na into the mucosal tissue after administration of 22Na into the intestinal lumen is not changed in presence of O and D. 4. We conclude that the net transport of sodium and water from blood to lumen under the influence of O and D occurs mainly via the intercellular way.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00498868
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Comparative study of the effect of cholera toxin and sodium deoxycholate on the paracellular permeability and on net fluid and electrolyte transfer in the rat colon (1980)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 312 (1980), S. 91-97 
    Details
    ISSN: 1432-1912
    Keywords: Rat colon mucosa ; Cholera toxin ; Deoxycholate ; Permeability ; Morphology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The effect of deoxycholate and cholera toxin on the transfer of water, sodium, potassium and chloride and on mucosal permeability was studied in perfusion experiments on rat colon in vivo. The influence of both secretagogues on surface morphology was assessed by scanning electron microscopy. 2. Deoxycholate turned the absorption of water, sodium and chloride to secretion and enhanced potassium secretion. Cholera toxin induced water and sodium secretion, inhibited chloride absorption and enhanced potassium secretion. 3. Deoxycholate increased reversibly the mucosal permeability as measured by the colonic clearance of 51CrEDTA and glucose, whereas cholera toxin decreased the colonic 51CrEDTA clearance. 4. Deoxycholate caused protrusion of the luminal cell surface and an increase of exfoliation of epithelial cells. The epithelial continuity was preserved. The only change induced by cholera toxin was an enhanced mucus extrusion. 5. Our results are consistent with the view that deoxycholate causes fluid secretion by filtration whereas cholera toxin enhances the secretory activity of the epithelium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00502580
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    Paper (German National Licenses)
    Fulltext
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