ISSN:
1432-2072
Keywords:
Haloperidol
;
Fentanyl
;
Dexetimide
;
Brain Self-Stimulation
;
Medial Forebrain Bundle
;
Dopamine
;
Neostriatum
;
Antipsychotic
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Haloperidol (0.08 mg/kg) or fentanyl (0.16 mg/kg) injected subcutaneously suppressed bar-pressing for brain-stimulation in rats, implanted with electrodes in the lateral hypothalamic area of the medial forebrain bundle. Increasing doses: 0.04, 0.16, 0.63 and 2.50 mg/kg of the central anticholinergic dexetimide gradually antagonized the haloperidol effects. The highest dose of dexetimide did not reduce the fentanyl-induced inhibition. The results, together with a literature survey on the anticholinergic effects on neuroleptic-induced catalepsy and inhibition of avoidance behavior, are related to biochemical findings and clinical effects.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00428929
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