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  • 1
    Electronic Resource
    Electronic Resource
    Effect of dithiocarb and dimethyl sulfoxide on irreversible binding of 14C-bromobenzene to rat liver microsomal protein (1979)
    Springer
    Archives of toxicology 42 (1979), S. 289-293 
    Details
    ISSN: 1432-0738
    Keywords: Bromobenzene ; Diethyl dithiocarbamate ; Dimethyl sulfoxide ; Irreversible binding ; Rat liver microsomes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The irreversible binding of [14C]-bromobenzene to rat liver microsomal protein in vitro was inhibited by dithiocarb and DMSO. Dithiocarb suppressed this binding in a time- and concentration-dependent manner (I50 = 4.5 10−5 M). DMSO reduced the degree of covalent binding by 61% from 5 x 10−5 M to 8 × 10−4 M. Dithiocarb was also effective in inhibiting irreversible binding of bromobenzene to liver protein in vivo. Our results are consistent with the hypothesis that dithiocarb exerts its antihepatotoxic efficacy by depressing microsomal mixed-function oxidase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00334843
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Inhibition of the hepatotoxicity of paracetamol and its irreversible binding to rat liver microsomal protein (1980)
    Springer
    Archives of toxicology 45 (1980), S. 61-65 
    Details
    ISSN: 1432-0738
    Keywords: (+)-Cyanidanol-3 ; Diethyl ditbiocarbamate ; Dimethyl aminoethanol ; Dimethyl sulfoxide ; Hepatotoxicity ; Irreversible binding ; Rat liver microsomes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Dithiocarb and (+)-cyanidanol-3 prevented paracetamol-induced liver injury in rats in vivo. Both, as well as two other antihepatotoxic agents, deanol and DMSO, inhibited covalent binding of [3H]-paracetamol to rat liver microsomal proteins in vitro. Dithiocarb and (+)-cyanidanol-3 were the most effective inhibitors. The concentrations of the antidotes yielding 50% inhibition (I50) valued 1 · 8 × 10−5 M for dithiocarb and 2 · 1 × 10−5 M for (+)-cyanidanol-3.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303296
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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