ISSN:
1432-069X
Keywords:
Atopic dermatitis
;
IgE
;
Langerhans cells
;
Dinitrochlorobenzene
;
Atopic respiratory disease
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary To see whether or not IgE-bearing epidermal Langerhans cells are specific to skin lesions of atopic dermatitis (AD), we performed immunohistochemical and immunoelectron microscopic examinations of dinitrochlorobenzene (DNCB) contact dermatitis lesions provoked in uninvolved skin of eight patients with AD. In all of the eight examined, IgE-positive epidermal Langerhans cells were observed in the DNCB dermatitis lesions. Typical staining of anti-IgE was absent in the epidermis of normal-appearing skin of five patients with AD. Thus, it is likely that IgE positive epidermal Langerhans cells non-specifically occur in different eczematous diseases provoked in patients with AD.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00375722
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