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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 76 (1988), S. 46-54 
    ISSN: 1432-0533
    Keywords: Polyradiculoneuritis ; Protozoa ; Schwann cell destruction ; Axon degeneration ; Dog
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Four pups in a litter of eight Labrador Retrievers suddenly developed hind limb weakness. In three, paralysis ascended rapidly resulting in quadriplegia, cervical weakness, dysphagia and death. Postmortem examination revealed a severe polyradiculoneuritis in which roots, ganglia, and spinal and cranial nerves were heavily infiltrated by lymphocytes, plasma cells and macrophages and contained abundant protozoan pseudocysts. On sections of the brain and spinal cord protozoa were less frequent and appeared independent of the glial nodules which marked focal areas of necrosis. The organisms innitially were thought to beToxoplasma gondii, but this supposition was not supported by serological, immunocytochemical, or electron microscopic findings. Ultrastructurally the organisms resembled an unidentified sporozoan parasite, which has been reported in the CNS of dogs in Scandinavia. The inflamed spinal roots contained many degenerated and demyelinated axons. Electron microscopic studies indicated that the tachyzoite-like organisms, through their invasive and proliferative activities, brough about many of the degenerative changes in the Schwann cells and axons of the spinal roots and nerves.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 31 (1948), S. 1617-1623 
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch Reduktion mit Lithiumaluminiumhydrid wurde aus den entsprechenden Estern von α-Aminocarbonsäuren die folgenden Aminoalkohole dargestellt: D, L-Phenylalaninol, L(-)-Phenylalaninol, L(-)-Tyrosinol, L(+)-Alaninol, L(+)-Leucinol, L,(+)-2-Oxymethylpyrrolidin (L(+)-Prolinol), L(+)-2-Aminobutandiol-(1,4) (L(+)-Asparaginol), D, L-2-Aminobutandiol-(1,4) (D, L-Asparaginol) und 2-Amino-propandiol-( 1,3).
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 32 (1949), S. 1156-1157 
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch Reduktion mit Lithiumaluminiumhydrid wurden aus L-Valin-methylester L-Valinol und aus L-Tyrosin-methylester L-Tyrosinol in guten Ausbeuten hergestellt.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 32 (1949), S. 1936-1938 
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Durch Reduktion von Dibenzoyl-L-histidinmethylester mit LiAlH4 wurden Monobenzoyl-L-histidinol und aus letzterem durch Verseifung L-Histidinol hergestellt. Letztere Verbindung zeigt ähnliche pharmakologische Wirkung wie Histamin, aber erst in 1000-3000 mal höherer Dosis.
    Type of Medium: Electronic Resource
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