ZIB

Treffer pro Seite

Treffer 1 - 3 | 3 Treffer

Sortierung

Digitale Medien

Synthetic phospholipids as substrates for phospholipase C from Bacillus cereus

Ries, U. ; Fleer, E.A.M. ; Unger, C. ; [weitere]

Amsterdam : Elsevier

Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 1125 (1992), S. 166-170

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 0005-2760

Schlagwort(e): Alkylphosphocholine ; Diacylglycerol ; Lysophospholipid ; Phospholipase C ; Synthetic phospholipid

Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Thema: Biologie , Chemie und Pharmazie , Medizin , Physik

Materialart: Digitale Medien

URL: http://linkinghub.elsevier.com/retrieve/pii/0005-2760(92)90041-S

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Digitale Medien

Clinical and pharmacologic phase I study of Cemadotin—HCl (LU103793), a novel antimitotic peptide, given as 24-hour infusion in patients with advanced cancer (1998)

Mross, K. ; Berdel, W. E. ; Fiebig, H. H. ; [weitere]

Springer

Annals of oncology 9 (1998), S. 1323-1330

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1569-8041

Schlagwort(e): Cematodin–HCL ; Dolastin 15 analog ; phase I study

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract Purpose: To determine the maximum tolerable dose (MTD), principal toxicity, and pharmacologic behaviour of Cemadotin—HCl, a novel antimitotic peptide. Patients and methods: Cemadotin—HCl (10.0 to 27.5 mg/m2/day every three weeks) was administered as a 24-hour intravenous (i.v.) continuous infusion to patients with advanced cancer. Pharmacokinetic analyses were performed during the first treatment cycle. Blood samples were taken over 48 hours and analyzed by radioimmunoassay. Results: Hypertension was the dose-limiting toxicity (DLT). This type of toxicity was observed at all dose levels, but grade 3 (CTC) was observed only at dose levels 20.0, 25.0 and 27.5 mg/m2. This effect was reversible but in three patients associated with signs of cardiac ischemia. Other significant toxic effects were neutropenia, asthenia, tumor pain and transient liver enzyme elevation. A linear pharmacokinetics was observed. The best curve fit was obtained with a two-compartment model with a terminal half-life of ≈10 hours at each dose level, a volume of distribution at steady state of ≈9 l/m2 and a total clearance of ≈0.6 l/hour/m2. Neither partial nor complete responses were observed although minor tumor regressions were seen in a patient with carcinoma of unknown primary (CUP) and in another patient with liver metastases from a colon cancer. Conclusions: Hypertension was the dose-limiting toxicity of Cemadotin—HCl administered as a continuous 24-hour infusion. The recommended dose for further evaluation of its anticancer efficacy in disease-oriented phase II studies with this schedule is 15.0 mg/m2. The nature of the principal cardio-vascular toxicity remains unclear. The observed toxicities appeared to be significant but manageable.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1023/A:1008430515881

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Digitale Medien

Ueber den Ultramarin (1872)

Unger, C.

Weinheim : Wiley-Blackwell

Berichte der deutschen chemischen Gesellschaft 5 (1872), S. 893-896

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 0365-9496

Schlagwort(e): Chemistry ; Inorganic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/cber.18720050289

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Treffer 1 - 3 | 3 Treffer