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  • 1
    Electronic Resource
    Electronic Resource
    Controlled-release levodopa/benserazide (Madopar HBS): clinical observations and levodopa and dopamine plasma concentrations in fluctuating parkinsonian patients (1990)
    Springer
    Journal of neurology 237 (1990), S. 24-28 
    Details
    ISSN: 1432-1459
    Keywords: Parkinson's disease ; Controlled release ; Levodopa ; Dopamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In five levodopa (l-dopa)-treated patients with Parkinson's disease with severe fluctuations of motor performance, plasma l-dopa as well as dopamine levels were measured during 2 days, first under optimal standard l-dopa with peripheral decarboxylase inhibitor (PDI) and then after a dose adjustment period using slow-release l-dopa/benserazide (Madopar HBS) in an open inpatient trial. Three patients benefited from the slow-release preparation; two patients deteriorated with a tendency to have an unpredictable response, a delay to turn “on” with the first dose in the morning, as well as an increase in dyskinesia corresponding to l-dopa cumulation during the day. These problems were subsequently also seen during the follow-up period of 1 year in those patients who benefited from Madopar HBS as inpatients. This might indicate that patient compliance is more difficult with the new formulation. After 1 year all patients had returned to their previous standard l-dopa/PDI treatment. l-Dopa levels continued to fluctuate, but to a lesser degree with Madopar HBS. The equivalent l-dopa dosage had to be increased by 56% (29–100%) with Madopar HBS while mean dopamine levels increased in four patients (by 47–257%) without the occurrence of peripheral side-effects. This implies that with the new formulation more l-dopa is metabolized to dopamine and explains the necessity to increase the equivalent l-dopa dosage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319663
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Enzymaktivität der PGM1 in Erythrozyten (1990)
    Springer
    International journal of legal medicine 103 (1990), S. 609-612 
    Details
    ISSN: 1437-1596
    Keywords: PGM-phenotypes ; Enzyme-activity ; Silent allel ; PGM-Phanotypen ; Enzym-Aktivität ; Null-Allel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Enzymaktivität der erythrozytdren Phosphoglucomutase wurde in 142 Hdmolysaten bestimmt. Die PGM-Phänotypen wurden mittels Isoelektrofokussierung auf Polyacrylamid-Gel ermittelt. Dabei konnten 10 verschiedene Phanotypen dargestellt werden. Die mittlere Enzymaktivität dieser 10 Phänotypen weist signifikante Unterschiede auf. Ein stummes Allel bzw. ein Allel mit reduzierter PGM-Aktivität wurde nicht festgestellt. Es zeigte sich eine Korrelataion zwischen Enzymaktivitat und isoelektrischem Punkt der vier Homozygoten.
    Notes: Summary The enzyme activity of phosphoglucomutase (PGM) has been investigated in red cell haemolysates from 142 individuals and compared to the sub-type as determined by isoelectric focusing. The 10 phenotypes showed significant differences in PGM-activity which indicates that there is a correlation between the level of activity and the isolelectric point of homozygotes. No indication of silent alleles or alleles with reduced activity was found in this collective.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00202722
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Enzymaktivität der PGM1 in Erythrozyten (1990)
    Springer
    International journal of legal medicine 103 (1990), S. 609-612 
    Details
    ISSN: 1437-1596
    Keywords: PGM-phenotypes ; Enzyme-activity ; Silent allel ; PGM-Phänotypen ; Enzym-Aktivität ; Null-Allel
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Enzymaktivität der erythrozytären Phosphogluco-mutase wurde in 142 Hämolysaten bestimmt. Die PGM-Phänotypen wurden mittels Isoelektrofokussierung auf Polyacrylamid-Gel ermittelt. Dabei konn-ten 10 verschiedene Phänotypen dargestellt werden. Die mittlere Enzymakti-vität dieser 10 Phänotypen weist signifikante Unterschiede auf. Ein stummes Allel bzw. ein Allel mit reduzierter PGM-Aktivität wurde nicht festgestellt. Es zeigte sich eine Korrelataion zwischen Enzymaktivität und isoelektrischem Punkt der vier Homozygoten.
    Notes: Summary The enzyme activity of phosphoglucomutase (PGM) has been investigated in red cell haemolysates from 142 individuals and compared to the sub-type as determined by isoelectric focusing. The 10 phenotypes showed significant differences in PGM-activity which indicates that there is a correlation between the level of activity and the isolelectric point of homozygotes. No indication of silent alleles or alleles with reduced activity was found in this collective.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01261426
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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