ISSN:
1432-2072
Keywords:
Prolactin
;
Dopamine
;
Buspirone
;
Dopamine receptors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Buspirone, an effective antianxiety compound, produced a dose-dependent, relatively prolonged increase in rat plasma prolactin (PRL) levels. The stimulation of PRL secretion by buspirone was additive with the effect of α-methyl-p-tyrosine (AMPT) or γ-butyrolactone. In vitro, buspirone itself had no effect on the release of PRL from rat pituitary glands but it blocked the inhibitory action of dopamine (DA). Buspirone also increased DA turnover in the striatum as measured by the AMPT-induced depletion of striatal DA levels. These results demonstrate the ability of buspirone to block pituitary and striatal DA receptors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00470587
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