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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 281 (1989), S. 193-197 
    ISSN: 1432-069X
    Keywords: Drug solubility ; Ointment vehicle ; Drug efficacy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a bilateral paired comparison (randomized double-blind study) 31 dermatitis patients (atopic and contact dermatitis) were tested with two ointments containing 0.0056% betamethasone-17-benzoate. One ointment was applied on each side of the body. The topical formulations differed in their solution capacities for the drug by a factor of about 50 (solution-type: high mutual affinity between drug and vehicle; suspensiontype: low affinity). The different antiinflammatory effects were studied visually by assessing five symptoms: erythema, scaling, infiltration, lichenification, and excoriation. On the 5th day, 73% of the patients showed significant differences between the sides in favor of the suspension-type ointment (Wilcoxon test). Blanching tests on 30 volunteers confirmed the result. The in vitro drug release, however, was faster with the solution-type ointment. The efficacy of an ointment can be increased greatly, if the solution capacity for the drugs is low, and thus the partition coefficient between the stratum corneum (barrier of the skin) and the vehicle is high. As long as the barrier is not damaged completely, the difference in drug release is not the determining factor for the effect.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 51 (2000), S. 935-938 
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Psoriasis ; Vernarbende Alopezie ; HIV-Infektion ; Acquired Immunodeficiency Syndrome ; Keywords Psoriasis ; Scarring alopecia ; HIV-infection ; Acquired immunodeficiency syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Scarring alopecia is a rare complication of scalp psoriasis which in most cases occurs in areas of long-standing lesions. A HIV-positive 35 year-old Moroccan patient (CDC C3) developed scalp psoriasis with scarring alopecia within five weeks. Topical antipsoriatic therapy resulted in alleviation of psoriatic lesions and stopped the progression of the alopecia. This case report suggests potential pathogenic links between scalp psoriasis, scarring alopecia, and HIV-infection. In addition, early and efficient antipsoriatic treatment is recommended to prevent the disfiguring complication of scarring alopecia.
    Notes: Zusammenfassung Vernarbende Alopezie ist eine seltene Komplikation der Psoriasis capitis. In den wenigen bisher beschriebenen Fällen trat sie nach längerem Bestehen der Psoriasis auf. Wir berichten über den ungewöhnlichen Fall eines HIV-positiven 35-jährigen marokkanischen Patienten (CDC C3), bei dem sich innerhalb weniger Wochen im Bereich des behaarten Kopfes psoriatische Läsionen mit vernarbender Alopezie entwickelten. Konsequente topische antipsoriatische Therapie führte zum Rückgang der psoriatischen Hautveränderungen und zum Stillstand der Alopezie. Anhand dieses Falls werden mögliche pathogenetische Zusammenhänge zwischen Psoriasis, vernarbender Alopezie und HIV-Infektion diskutiert sowie auf die Notwendigkeit frühzeitiger und suffizienter antipsoriatischer Therapie bei dieser seltenen Komplikation hingewiesen.
    Type of Medium: Electronic Resource
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