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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 752-752 
    ISSN: 1435-2451
    Keywords: Duct occlusion ; Pancreatic allografting ; Gangocclusion ; Pankreastransplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bisher wurden 12 konsekutive segmentale Pankreastransplantationen bei 11 Patienten durchgeführt, wobei in allen Fällen die Gangocclusion mit Ethibloc angewandt wurde. 5 Pankreastransplantate funktionieren derzeit: 2 Jahre, 1 Jahr, 3 Monate, 2 Monate, 1,5 Monate. Bisher haben wir keinen Hinweis dafür (weder klinisch noch nuklear-medizinisch noch histologisch), daß ein Pankreastransplantat aufgrund einer sekundär induzierten Pankreasfibrose versagte. Wir sehen daher keinen Grund, die Technik der Gangocclusion mit Ethibloc bei der klinischen Pankreastransplantation im Augenblick zu verlassen.
    Notes: Summary Twelve consecutive segmental pancreatic allografts have been performed in 11 patients using the technique of duct obstruction with Ethibloc in all cases. Five pancreatic allografts are currently functioning (2 years, 1 year, 3 months, 2 months, 1.5 months). There is no evidence (neither by clinical observations, nor by scan or histological studies) that a pancreatic allograft failed due to secondary fibrosis. Thus, we will continue to use the technique of Ethibloc occlusion in clinical pancreatic transplantation.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of nuclear medicine 17 (1990), S. 38-41 
    ISSN: 1619-7089
    Keywords: Monoclonal antigranulocyte antibody ; NCA-95-specific antibody ; Bone marrow scintigraphy ; Antibody liver uptake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The influence of reconstituting a murine monoclonal IgG1 antibody kit with pertechnetate technetium 99m on antibody distribution in the liver, spleen and sternal bone marrow of patients was examined. The99mTc-labelled antibody used is directed against nonspecific cross-reacting antigen (NCA-95) and carcinoembryonic antigen (CEA) and has been successfully applied for imaging tissue inflammation and bone marrow scanning. Radioactivity uptake was determined in the liver, spleen, bone marrow and a precordial background region in a consecutive series of 25 patients, examined with an antibody preparation, routinely radiolabelled according to the manufacturer's recommendations and in 14 patients, in whom the antibody was reconstituted with special care, avoiding bubble formation and dropping of buffer into the antibody-containing vial. Gentle compared with routine antibody reconstitution caused a highly significant reduction of the antibody uptake in the liver, as determined by count densities, normalized to injected dose and acquisition time (13.2 ± 5.5 vs 20.1 ± 6.0 cpm per pixel, x±SID,P=0.008). The liver to background ratio was reduced from 3.4 ± 1.4 to 1.9 ±0.5 (P 〈 0.001). Spleen, sternal bone marrow and precordial background count rates were not significantly affected. These results clearly demonstrate that gentle antibody reconstitution can decrease non-specific antibody uptake in the liver by 34% ± 6.4% (x ± SEM). Thus, scan quality is improved, and the potential deleterious camouflage of underlying structures is avoided.
    Type of Medium: Electronic Resource
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