ISSN:
1573-2568
Keywords:
OCTREOTIDE
;
ERYTHROMYCIN GASTRIC
;
MANOMETRY
;
GASTRIC MYOELECTRIC ACTIVITY
;
GASTROPARESIS
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Simultaneous recordings of gastric manometry andmyoelectrical activity were made in 10 patients withgastroparesis. Intravenous erythromycin (100 mg) wasadministered in the fasting state for a period of 30 min. Subcutaneous injection of octreotide(100 μg) was administered before one of the fouridentical test meals. It was found that octreotidesignificantly decreased the antral motility index(30-min fasting: 4.51 ± 1.04 vs 1.75 ±0.97, P 〈 0.02; 60-min fed: 5.16 ± 1.44 vs 3.4± 1.41, P 〈 0.05) and the dominant power ofthe EGG (fasting power: 35.19 ± 1.54 vs 30.84± 1.57 dB, P 〈 0.004; postprandial powerincrease: 5.52 ± 1.06 vs 0.27 ± 0.87, P〈 0.001). Erythromycin significantly increased theantral motility index (3.16 ± 0.96 vs 9.5± 0.61, P 〈 0.001) and the dominant power ofthe EGG (28.86 ± 1.57 dB vs 33.55 ± 1.59dB, P 〈 0.005) in the fasting state. An improvement in theregularity of the gastric slow wave was also noted witherythromycin. It was concluded that: (1) the inhibitoryeffect of octreotide on postprandial gastric motility and myoelectrical activity suggests thatcaution should be exercised when octreotide is used inpatients with gastroparesis; and (2) the stimulatoryeffect of erythromycin on gastric myoelectrical activity may enhance gastric motility and gastricemptying in patients with gastroparesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1018876021156
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