ISSN:
1573-2568
Keywords:
INTESTINAL MOTILITY
;
SLOW WAVE
;
JEJUNUM
;
ATROPINE
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The postprandial characteristics of jejunalmyoelectrical activity and its mediation via cholinergicnerves were investigated in this study. Four pairs ofbipolar electrodes were implanted on the serosa of the proximal jejunum of nine female hounddogs (14-22 kg). In the control session, the recordingof jejunal myoelectrical activity was made for 30 min inthe fasting state and for 90 min after a solid meal (0.45 kg, 838 kcal). The study sessionfollowed the same protocol except that a bolus of 0.25mg/kg atropine was injected intravenously 30 min afterthe meal. Computerized spectral analysis was performed to calculate the frequency, power, andpercentage of 17-22 cycles/min (cpm) slow waves. Aspecial artificial neural network program was applied tocompute the spike bursts superimposed on slow waves. All data were expressed as mean ± SE. Thepostprandial frequency of the jejunal slow waves wassignificantly increased from 18.42 ± 0.28 cpm inthe fasting state to 18.95 ± 0.22, 19.28 ±0.23, and 19.28 ± 0.22 cpm during the first, second, andthird 30-min periods after the meal (all P 〈 0.03 incomparison with the fasting state). The percentage ofthe slow waves superimposed with spike bursts was increased from 19.33 ± 3.90% at fastingstate to 35.16 ± 2.76%, 32.87 ± 4.06%, and34.88 ± 3.51% during the first, second, and third30-min periods after the meal (all P 〈 0.03 incomparison with fasting state). Atropine abolished thepostprandial increases in the frequency of slow wavesand the number of spike bursts. No significantpostprandial changes in the power and the percentage of17-22 cpm slow waves were observed. In conclusion,the postprandial response of the jejunal slow wavesafter a solid meal presents as an increase of thefrequency of slow waves and the number of the spikebursts which can be abolished by atropine, and thepostprandial response of the jejunal slow waves is aneural reflex dominantly mediated via vagal cholinergicnerves.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1026638221467
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