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  • Ehrlich ascites tumor  (2)
  • Flexible Bronchoskopie  (2)
  • Graft rejection  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Induction of cell arrest at G1/S and in G2 after treatment of Ehrlich ascites tumor cells with metallocene dichlorides and cis-platinum in vitro (1983)
    Springer
    Journal of cancer research and clinical oncology 106 (1983), S. 44-52 
    Details
    ISSN: 1432-1335
    Keywords: Metallocene dichlorides ; cis-Diammine-dichloroplatinum(II) ; Ehrlich ascites tumor ; Cytokinetics in vitro
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The influence of in vitro application of the cytostatic agents titanocene dichloride (TDC), vanadocene dichloride (VDC), and cis-diamminedichloroplatinum(II) (DDP) on the cytokinetic behavior of EAT cells was investigated. All three substances induced similar cytokinetic phenomena that are characterized on the one hand, by an accumulation of cells in the late S phase and in the G2 phase during exposure periods of 8 to 20 h. On the other hand, some cells were apparently arrested at the end of the G1 phase and, after removal of the cytostatic agents, moved through the following S, G2, and M phases as synchronized cell populations. In view of this unusual cytokinetic pattern of multiple effects, it is argued that the striking similarities in cytokinetic behavior after treatment with the three different cytostatic substances indicate analogies in their molecular mechanisms of action. The different alteration patterns observed after in vivo application of the drugs are obviously due to additional processes occurring only in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00399896
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  • 2
    Electronic Resource
    Electronic Resource
    Wirkung von Acetylsalicylsäure und einem Pyrido-pyrimidin-Derivat auf die Abstoßung allotransplantierter Nieren im Tierexperiment (1975)
    Springer
    Research in experimental medicine 165 (1975), S. 67-73 
    Details
    ISSN: 1433-8580
    Keywords: Renal transplantation ; Graft rejection ; Platelet thrombi ; Antiaggregating drugs ; Nierentransplantation ; Transplantatabstoßung ; Thrombocytenthromben ; Thrombocytenaggregationshemmende Pharmaka
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Thrombocytenaggregationshemmende Pharmaka — Acetylsalicylsäure und 2-Piperazinyl-4-thiomorpholino-pyrido(3,2-d)-pyrimidin-Sulfattrihydrat—werden in ihrer Wirkung auf Abstoßungsreaktionen bei allotransplantierten Nieren an Hunden untersucht. Klinisch findet sich keine Wirksamkeit der Medikamente, dagegen zeigen interessanterweise die histologischen Befunde bei der Acetylsalicylsäuregruppe eine verminderte Abstoßungsreaktion.
    Notes: Summary The effects of anti-thrombotic drugs—Acetyl-salicylic-acid and 2-Piperazinyl-4-thiomorpholino-pyrido(3,2-d)-pyrimidin-sulfat-trihydrat—on rejection reactions of renal allografts in dogs have been studied. From the clinical point of view no effectiveness of the two drugs can be found, whereas the histological findings do clearly show diminished rejection reactions in the Acetylsalicylic-acid group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01856451
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  • 3
    Electronic Resource
    Electronic Resource
    Der Einfluß von Azetylsalizylsäure und Dipridamol auf die Abstoßung allotransplantierter Hundenieren bei präsensibilisierten Empfängern (1976)
    Springer
    Research in experimental medicine 169 (1976), S. 109-122 
    Details
    ISSN: 1433-8580
    Keywords: Renal transplantation ; Graft rejection ; Platelet thrombi ; Antiaggregating drugs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of antiaggregating agents - acetylsalicyclic acid (ASA) and dipyridamol - on the rejection of allotransplanted canine kidneys in presensitized animals were studied. Blood flow dropped more markedly in the control group than in the group treated with ASA and dipyridamol. 24 hours after transplantation the blood flow in this group was significantly higher than in the control group (p 2,5 %) and in the third group treated with dipyridamol alone. The cellular rejection started earlier and was more pronounced in the control group. Only in this group vascular rejection and microthrombi were demonstrated. Urine output ceased 24 to 60 hours after transplantation. The immunosuppressive, antiphlogistic and platelet antiaggregating effect of the combined ASA and dipyridamol therapy is thought to be responsible for the better results in this group. In this experimental model the combined treatment of ASA and dipyridamol results in a later onset of cellular rejection, in better blood-flow of the kidney and later onset of anuria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851172
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  • 4
    Electronic Resource
    Electronic Resource
    Cytokinetic behavior of Ehrlich ascites tumor after in vivo treatment with cis-diamminedichloroplatinum(II) and metallocene dichlorides (1981)
    Springer
    Journal of cancer research and clinical oncology 102 (1981), S. 21-30 
    Details
    ISSN: 1432-1335
    Keywords: cis-Diamminedichloroplatinum(II) ; Titanocene dichloride ; Vanadocene dichloride ; Ehrlich ascites tumor ; Pulse-cytophotometry ; cis-Diammindichloroplatin(II) ; Titanocen-dichlorid ; Vanadocen-dichlorid ; Ehrlich-Aszites-Tumor ; Impulscytophotometrie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Gegenstand der Untersuchungen ist der Einfluß einer in-vivo-Behandlung mit optimal tumorhemmenden Dosen von cis-Diammindichloroplatin(II) (DDP), Titanocen-dichlorid (TDC) und Vanadocen-dichlorid (VDC) auf das impulscytophotometrisch bestimmte DNA-Verteilungsmuster und die Mitoseaktivität von EAT-Zellen. Während DDP eine sofortige und langandauernde Unterdrückung der Zellteilungen, jedoch keine Veränderung des zellkinetischen Verhaltens von EAT-Zellen bewirkt, verursacht TDC die Ausbildung eines deutlichen,: 10–12 h nach Behandlung maximalen G2-Blocks. Im Falle von DDP und TDC werden die Tumorzellen einige Tage nach Behandlung durch Zellen des wirtstiereigenen Abwehrsystems beseitig. VDC hingegen ruft die Entstehung teilsynchroner Wellen nach einer vorübergehenden Mitosehemmung und einer reversiblen Zellakkumulation in der späten S-und der G2-Phase hervor. Darüber hinaus werden 5–16% der Zellen nach VDC-Behandlung polyploid.
    Notes: Summary The influence of an in vivo treatment with optimally tumor-inhibiting doses of cis-diamminedichloroplatinum(II) (DDP), titanocene dichloride (TDC), and vanadocene dichloride (VDC) on the DNA distribution pattern, determined by pulse-cytophotometry, and on the, mitotic activity of EAT cells is investigated. Whereas DDP causes an immediate and, long-lasting decrease of mitoses but no disturbances of the EAT cell kinetics, a marked G2 block with a maximum at 10–12 h a. t. and an irreversible and extensive mitotic depression is evoked by TDC. In the case of DDP and TDC, the tumor cells are removed several days a. t. by cells belonging to the defensive system of the host animals. In contrast, VDC induces partially synchronized waves after a transient suppression of mitoses and reversible cell accumulation in the late S and in the G2 phases. Additionally, 5–16% of the cells become polyploid after VDC treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00410531
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  • 5
    Electronic Resource
    Electronic Resource
    350. Das flexible Bronchoskop zur Diagnostik und Therapie (1983)
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 904-904 
    Details
    ISSN: 1435-2451
    Keywords: Flexible bronchofiberscope ; Flexible Bronchoskopie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Flexible Bronchoskope haben folgende Vorteile gegenüber den starren Geräten: in Lokalanästhesie kann der Patient ambulant untersucht werden. Weiter peripher gelegene, dadurch kleinere Tumore können histologisch gesichert werden. Gezielte Bronchographien mit Absaugung des Kontrastmittels aus der Peripherie sind möglich, kleine Bronchialeinrisse peripher können erkannt werden. Fremdkörper sind auch mit flexiblen Instrumenten leicht zu entfernen. Die postoperative Bronchialtoilette mit dem flexiblen Bronchoskop gewährleistet hohe Effektivität und geringe Verletzungsgefahr des Bronchialepithels. In Diagnostik und Therapie ist das starre durch das flexible Bronchoskop überholt.
    Notes: Summary Flexible bronchoscopes have advantages over rigid instruments. In an outpatient under local anesthesia, more peripheral, smaller tumors can be histologically proved. Bronchography can be performed purposefully with aspiration of the contrast medium. Small peripheral ruptures of the bronchial tree can be recognized. All kinds of foreign bodies can be removed by flexible instruments. Postoperative bronchial cleaning is highly effective and there is only a low risk of injuring the bronchial epithelium. For diagnosis and therapy the rigid instruments are antiquated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276176
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  • 6
    Electronic Resource
    Electronic Resource
    261. Optimierte Bronchialtoilette mit dem flexiblen Bronchoskop (1983)
    Springer
    Langenbeck's archives of surgery 361 (1983), S. 770-771 
    Details
    ISSN: 1435-2451
    Keywords: Flexible bronchofiberscopy ; Bronchial cleansing ; Flexible Bronchoskopie ; Bronchialtoilette
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bronchialtoilette beginnt mit Entfernung von Fremdkörpern. Über eine Spezialmaske (Groitl) können diese auch bei Kindern mit flexiblen Bronchoskopen entfernt werden. Die herkömmliche Methode der Katheterabsaugung verletzt das Bronchialepithel erheblich. Mit dem flexiblen Bronchoskop können beide Seiten des Bronchialsystems gleich gut erreicht und von Sekret gereingt werden. Die Technik ist einfach. Jeder auf der Intensivstation tätige Arzt sollte mit dem flexiblen Bronchoskop die Bronchialtoilette durchführen können. Die Erfahrung von ca. 7000 bronchoskopischen Absaugungen erklärt den Erfolg und macht das Blähen bei Atelektasen überflüssig.
    Notes: Summary Cleansing the bronchial tubes includes, first of all, removal of foreign bodies. Via a special mask (Groitl) foreign bodies can be taken out even in children. The usual method suctioning with a catheter can injure the bronchial epithelium. With the flexible bronchofiberscope both sides of the bronchial tree can be reached and cleansed of secretions. The technique is simple, and every physician in an intensive care unit should be able to handle a flexible scope to clean thebronchial tubes. In more than 7,000 cases this method has proven successful and has eliminated the necessity of using the inflating procedure in atelectases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01276086
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