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  • 1
    ISSN: 1432-1335
    Keywords: Antineoplastic efficacy ; Melphalan ; Diazoxide ; Insulin ; Mammary carcinoma ; Sprague-Dawley rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The anticancer activity of melphalan andN-(2-chloroethyl)-N-nitrosocarbamoyl-ω-lysine (CNC-ω-Lys), was compared in the autochthonous, methylnitrosourea-induced mammary carcinoma of the Sprague-Dawley rat. In addition, the influence on the therapeutic efficacy of the combination with diazoxide, causing a mild, reversible diabetes, and with insulin was investigated. The comparison of melphalan and CNC-ω-Lys clearly showed the superiority of melphalan. Both compounds displayed a significant tumour inhibition in their medium and the highest dosages in comparison to the untreated control. The combination with diazoxide resulted for almost all groups in an increased tumour inhibition. Only the lowest dose of CNC-ω-Lys + diazoxide did not reduce the tumour volume significantly versus the control group. The combination with insulin, however, resulted in a loss of tumour inhibition compared to the effect of the cytotoxic drug alone, although in these groups, too, a significant decrease of tumour volumes versus controls could be observed. Mortality was within tolerable limits (〈20%) through the treatment period for all experimental groups. Median lifespans were increased in all therapy groups, but no additional benefit could be observed in the combination treatment groups.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1335
    Keywords: Vitamins A, E ; Semisynthetic fatty diet ; Methylnitrosourea ; Mammary carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Prolonged supplementation of vitamins A and E (2500 IU and 11.3 IU/rat daily) in 10.3% and 21.6% fatty diets administered to methylnitrosourea-induced Sprague-Dawley rats caused alterations in plasma and liver levels of both vitamins as well as of the total lipids. Liver vitamin A levels increased steadily (more than four-fold) until termination of the experiment, whereas plasma vitamin A levels only showed a minor increase at the end of the study in comparison to rats fed a standard diet. Liver vitamin E levels initially showed no difference from those of rats treated with a standard diet, and were decreased at the end of the experiment, whereas the respective plasma levels were increased throughout the study, only showing a decrease relative to initial values at termination of the experiment. Plasma total lipids increased with age and following supplementation of the vitamins in the high-fat diet, whereas liver total lipids were influenced less by aging than by the fat and vitamin contents of the respective diets. The observed alterations were, however, not related to significant chemopreventive activity of the vitamins A and E contained in high-fat diets.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of cancer research and clinical oncology 116 (1990), S. 538-549 
    ISSN: 1432-1335
    Keywords: Androgen-linked alkylating agents ; Methylnitrosourea ; Mammary carcinoma ; Anticancer activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary This article gives a comprehensive survey on the anticancer activity of nitrosoureas linked to steroidal androgens in methylnitrosourea (MMU)-induced rat mammary carcinoma. cis-Androsterone, testosterone, 19-nortestosterone and 5-α-dihydrotestosterone were used as carrier hormones and were linked to various cytotoxic N-[N′-(2-chloroethyl)-N′-nitrosocarbamoyl] (CNC)-aminoacids and to N-(2-hydroxyethyl)-N′-(2-chloroethyl)-N′-nitrosourea hemisuccinate (HECNU-hemisuccinate). In the MNU-model used esters of dihydrotestosterone (DHT) invariably were more active and less toxic than those of testosterone, nortestosterone and cis-androsterone. Within the DHT esters of CNC-aminoacids those of CNC-glycine, CNC-methionine and CNC-alanine showed the highest antineoplastic activities and superiority compared with equimolar dosages of their unlinked mixtures. Additionally, CNC-alanine-DHT ester had the highest therapeutic ratio of all agents investigated. HECNU-hemisuccinate-DHT ester, on the other hand, achieved even higher antitumor activity at the optimal dose but had a narrower therapeutic ratio. No obvious correlation between antineoplastic efficacy and receptor binding affinity could be demonstrated, but, to be active, a conjugate apparently had to have some receptor binding affinity for both androgen and progesterone receptors. The results obtained indicate that linking antineoplastic agents to transport molecules with affinity to steroid receptors is a highly promising approach to obtain drugs with specific activity in steroid receptor containing tumors.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 0271-2091
    Keywords: Computer Extended Series ; Rotating Fluid Mechanics ; MACSYMA ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: We have reformulated the general problem of internal flow in a modern, high speed gas centrifuge with sources and sinks in such a way as to obtain new, simple, rigorous closed form analytical solutions. Both symmetric and antisymmetric drives lead us to an ordinary differential equation in place of the usual inhomogeneous Onsager partial differential equation. Owing to the difficulties of exactly solving this sixth order, inhomogeneous, variable coefficient ordinary differential equation we appeal to the power of perturbation theory and techniques. Two extreme parameter regimes are identified, the so-called semi-long bowl approximation and a new short bowl approximation. Only the former class of problems is treated here. The long bowl solution for axial drive is the correct leading order term, just as for pure thermal drive. New O(1) results are derived for radial, drag and heat drives in two dimensions. Then regular asymptotic, even ordered power series expansions for the flow field are carried out on the computer to O(ε4) using MACSYMA. These approximations are valid for values of ε near unity. In the spirit of Van Dyke, one can carry out this expansion process, in theory, to apparently arbitrary order for arbitrary but finite decay length ratio. Curiously, the flows induced by axial and radial forces are proportional for asymptotically large source scale heights, x*. Corresponding isotope separation integral parameters will be given in a companion paper.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 6 (1986), S. 395-401 
    ISSN: 0271-2091
    Keywords: Computer Extended Series ; Gas Centrifuge Theory ; MACSYMA ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Linearized, multidimensional, thermally driven flow in a gas centrifuge can be approximately described in regions away from the ends by Onsager's homogeneous pancake equation.1 Upon reformulation of the general problem, we find a new, simple and rigorous closed form, analytical solution by assuming a special separable solution and replacing the usual Ekman end cap boundary conditions with idealized impermeable, free slip boundary conditions. Then the flow may be described by an ordinary differential equation with solutions in terms of simple, classical functions. By identifying a small parameter, say ∊, defining the semi-long bowl approximation, and assuming a power series expansion in ∊, a sequence of asymptotic approximations to the master potential is obtained. Not surprisingly, the leading order term involves the well known ‘long bowl’ solution. Using the so-called ‘solving’ property of the 1-D pancake Green's function,2 we determine the next higher order solution. This recursive process is carried out on the computer to find all the terms up to O(∊4).Consequently, the solution of some complex rotating, viscous, heat conducting flow problems that normally require large mainframe computers can be better understood.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0271-2091
    Keywords: Finite Element Method ; Rotating Fluid Mechanics ; Slip Flow ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Linearized multidimensional flow in a gas centrifuge can be described away from the ends by Onsager's pancake equation. However a rotating annulus results in a slightly different set of boundary conditions from the usual symmetry at the axis of rotation. The problem on an annulus becomes ill-posed and requires some special attention. Herein we treat axially linear inner and outer rotor temperature distributions and velocity slip. An existence condition for a class of non-trivial, one-dimensional solutions is given. New exact solutions in the infinite bowl approximation have been derived containing terms that are important at finite gap width and non-vanishing velocity slip. The usual one-dimensional, axially symmetric solution is obtained as a limit. Our previously reported finite element algorithm has been extended to treat this new class of problems. Effects of gap width, temperature and slip conditions are illustrated. Lastly, we report on the compressible, finite length, circular Couette flow for the first time.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 2 (1982), S. 1-23 
    ISSN: 0271-2091
    Keywords: Transition ; Boundary Layers ; Models of Turbulence ; Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A computational procedure for compressible axisymmetric boundary layers, on bodies of revolution, in transition from laminar to turbulent flow, is introduced. The procedure is an extension of a former method, due to Patankar and Spalding.The flow field is computed by solution of four simultaneous equations for the momentum, the thermal energy, the turbulence energy amplitude and the turbulent scale.The results show good agreement with existing theoretical and experimental data.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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