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Digitale Medien

Increase of δ-Aminolevulinic Acid Dehydratase (ALAD) in rat erythrocytes in lead poisoning (1983)

Kajimoto, M. ; Kondo, M. ; Niwa, M. ; [weitere]

Springer

Archives of toxicology 52 (1983), S. 1-11

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ISSN: 1432-0738

Schlagwort(e): Lead poisoning ; Erythrocytes ; δ-Aminolevulinic acid dehydratase(ALAD) ; Rat ; Porphyrins

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Abstract The well known fact that the activity of δ-aminolevulinic acid dehydratase (ALAD: EC 4.2.1.24) is reduced in red cells of animals with lead poisoning was found to be upset, by using a modified method of Gibson's original procedure, for determination of activated ALAD activity. The modified method involves addition of 0.2 mM Zn2+ and then preheating the enzyme solution at 60° C for 5 min before following Gibson's original procedure. With this methodological modification, the ALAD activity of erythrocytes of rats poisoned with lead was found increased. Furthermore, the enzyme was purified from the peripheral blood of lead-poisoned rats. ALAD protein in peripheral blood was also determined by single radial immuno diffusion using rabbit anti-serum raised against rat liver ALAD. As the result, the ALAD activity obtained from the modified method was found to be directly proportional to the absolute amount of enzyme proteins determined both by chemically and immunochemically. The modified method for measuring true ALAD content in blood cells in lead poisoning is more reliable than previous ones.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00317977

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Digitale Medien

Stresses for an elastic half-space under a tilted rigid rectangular footing (1982)

Kondo, M. ; Sinclair, G. B. ; Brothers, P. W.

New York, NY [u.a.] : Wiley-Blackwell

International Journal for Numerical and Analytical Methods in Geomechanics 6 (1982), S. 483-490

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Details

ISSN: 0363-9061

Schlagwort(e): Engineering ; Engineering General

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Architektur, Bauingenieurwesen, Vermessung , Geologie und Paläontologie

Zusätzliches Material: 8 Ill.