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Comparative platelet anti-aggregant activity of D-cysteinolic acid analogues (1989)

Satake, M. ; Chiba, Y. ; Kohama, Y. ; [et al.]

Springer

Cellular and molecular life sciences 45 (1989), S. 1110-1112

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ISSN: 1420-9071

Keywords: D-Cysteinolic acid ; platelet aggregation ; inhibitor ; marine product ; 2-aminoethyl disulfide ; sardine

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary D-Cysteinolic acid (1) analogues with an S-C-C-N skeleton showed increased platelet anti-aggregant activity in the following order: 2-aminoethanesulfonic acids, thiazolidines, 2-aminoethanethiols and 2-aminoethyl disulfides. Methyl substitutions at the 2-position potentiated the activity. Of these analogues, bis [(R)-2-aminopropyl] disulfide was the most potent inhibitor of platelet aggregation, with about 600-fold the activity of (1).

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01950172

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Reconsiderations on singularity or crack tip elements (1979)

Yamada, Y. ; Ezawa, Y. ; Nishiguchi, I. ; [et al.]

Chichester [u.a.] : Wiley-Blackwell

International Journal for Numerical Methods in Engineering 14 (1979), S. 1525-1544

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ISSN: 0029-5981

Keywords: Engineering ; Engineering General

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Mathematics , Technology

Notes: Various singularity finite elements proposed so far are reviewed and their correlations are discussed. The method adopted in the comparative study is based on the singularity mapping or transformation technique. It is suggested that a compact design of computational routines is materialized by using the element which embodies singularity transformation and can be compatible with the notion of using the variable-number-nodes element in the general-purpose computer programs.

Additional Material: 11 Ill.