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  • Engineering General  (3)
  • Regulatory volume decrease  (3)
  • 1
    Digitale Medien
    Digitale Medien
    Ca2+-activated K+ channels are involved in regulatory volume decrease in acinar cells isolated from the rat lacrimal gland (1994)
    Springer
    The journal of membrane biology 141 (1994), S. 193-201 
    Details
    ISSN: 1432-1424
    Schlagwort(e): Ca2+-activated K+ channels ; Cell volume ; Regulatory volume decrease ; Tetraethylammonium ; Lacrimal acinar cells
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract The volumes of acinar cells isolated from rat lacrimal gland were measured on computer by video-imaging. Cells were found to swell on exposure to hypotonic solutions; they subsequently exhibited a regulatory volume decrease (RVD). RVD was inhibited in the absence of extracellular Ca2+, and by the K+ channel blocker tetraethylammonium chloride (2 mm TEA+). The possible involvement of K+ channels in RVD was further investigated in cell-attached patches. Exposing the cells to a hypotonic solution activated channels with a conductance of 141±6 pS (n=11). These channels were partially blocked by 0.5 mm TEA+, and channel activation was not observed in the absence of extracellular Ca2+. Experiments in the inside-out patch configuration demonstrated that the channels activated by hypotonie stress were “maxi” Ca2+-activated K+ channels. It is concluded that the opening of these channels plays an important role in RVD, by facilitating K+ loss from the cell.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00238253
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  • 2
    Digitale Medien
    Digitale Medien
    A volume-activated anion conductance in insulin-secreting cells (1996)
    Springer
    Pflügers Archiv 431 (1996), S. 363-370 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Outwardly rectifying ; Chloride channel ; Regulatory volume decrease ; Pancreaticβ-cell
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The whole-cell patch-clamp recording technique was used to measure volume-activated currents in K+-free solutions in RINm5F and HIT-T15 insulinoma cells and in dispersed rat islet cells. Cell swelling, induced by intracellular hypertonicity or extracellular hypotonicity, caused activation of an outwardly rectifying conductance which could be subsequently inactivated by hypertonic extracellular solutions. The conductance required adenosine 5′-triphosphate (ATP) in the pipette solution but was Ca2+ independent. Na+ and Cl− substitution studies suggested that the swelling-activated current is Cl− selective with a halide permeability sequence of Br 〉 Cl 〉 1. The conductance was reversibly inhibited by the anion channel inhibitors 4,4′-diisothiocyanatostilbene-2,2′-disulphonic acid (DIDS) and by 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB). Further evidence for a volume-activated anion conductance was provided by studies of volume regulation in insulin-secreting cells. When RINm5F cells were exposed to a hypotonic medium, the initial cell swelling was followed by a regulatory volume decrease (RVD). This RVD response was also inhibited by DIDS and by NPPB. These data therefore provide evidence for a volume-activated anion conductance in insulin-secreting cells which could be involved in the RVD following osmotic stress. A possible role for the conductance in hypotonically induced insulin release is also discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02207273
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  • 3
    Digitale Medien
    Digitale Medien
    A volume-activated anion conductance in insulin-secreting cells (1996)
    Springer
    Pflügers Archiv 431 (1996), S. 363-370 
    Details
    ISSN: 1432-2013
    Schlagwort(e): Key words Outwardly rectifying ; Chloride channel ; Regulatory volume decrease ; Pancreatic β-cell
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The whole-cell patch-clamp recording technique was used to measure volume-activated currents in K+-free solutions in RINm5F and HIT-T15 insulinoma cells and in dispersed rat islet cells. Cell swelling, induced by intracellular hypertonicity or extracellular hypotonicity, caused activation of an outwardly rectifying conductance which could be subsequently inactivated by hypertonic extracellular solutions. The conductance required adenosine 5′-triphosphate (ATP) in the pipette solution but was Ca2+ independent. Na+ and Cl− substitution studies suggested that the swelling-activated current is Cl− selective with a halide permeability sequence of Br 〉 Cl 〉 I. The conductance was reversibly inhibited by the anion channel inhibitors 4,4′-diisothiocyanatostilbene-2,2′-disulphonic acid (DIDS) and by 5-nitro-2-(3-phenylpropylamino) benzoic acid (NPPB). Further evidence for a volume-activated anion conductance was provided by studies of volume regulation in insulin-secreting cells. When RINm5F cells were exposed to a hypotonic medium, the initial cell swelling was followed by a regulatory volume decrease (RVD). This RVD response was also inhibited by DIDS and by NPPB. These data therefore provide evidence for a volume-activated anion conductance in insulin-secreting cells which could be involved in the RVD following osmotic stress. A possible role for the conductance in hypotonically induced insulin release is also discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02207273
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    The finite element solution of rapid cycling creep problems (1978)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 12 (1978), S. 1001-1024 
    Details
    ISSN: 0029-5981
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Mathematik , Technik allgemein
    Notizen: The paper describes a simplified finite element method for high temperature creep problems involving cyclic load and temperature. The principal assumptions, that the cycle time is small compared with characteristic material time scales, is appropriate for the moderate load levels which occur when structures are designed for life times measured in years and decades. Because of the simplicity of the method, thermal loading problems may be studied in some detail. A parametric study of a plane stress problem is presented. Characteristic deformation rates are related to reference stress and timperature quantities, thereby reducing the main features of the solution to a few important structural and material parameters.
    Zusätzliches Material: 13 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nme.1620120610
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  • 5
    Digitale Medien
    Digitale Medien
    Surface settlement of a finite elastic layer whose modulus increases linearly with depth (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 3 (1979), S. 37-47 
    Details
    ISSN: 0363-9061
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geologie und Paläontologie
    Notizen: An examination has been made of the behaviour of a finite layer of elastic material of constant Poisson's ratio, whose Young's modulus increases linearly with depth, and which rests on a rough rigid base. Values of surface settlement at the corner of a rectangular area of uniform loading are presented for values of Poisson's ratio of \documentclass{article}\pagestyle{empty}\begin{document}$ \frac{1}{2} $\end{document}, \documentclass{article}\pagestyle{empty}\begin{document}$ \frac{1}{3} $\end{document} and 0, and for wide ranges of degree of inhomogeneity and loading breadth to depth ratio.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nag.1610030105
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  • 6
    Digitale Medien
    Digitale Medien
    Numerical analysis of rafts on visco-elastic media using eigenvector expansions (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    International Journal for Numerical and Analytical Methods in Geomechanics 3 (1979), S. 63-78 
    Details
    ISSN: 0363-9061
    Schlagwort(e): Engineering ; Engineering General
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Architektur, Bauingenieurwesen, Vermessung , Geologie und Paläontologie
    Notizen: Problems of a raft on a visco-elastic continuum may be converted to equivalent elastic problems by means of a Laplace transformation. In this paper a numerical solution of the equivalent problem is obtained by finite element or other techniques. This solution is converted into the form of an eigenvector expansion and then transformed into a numerical solution to the original problem by inverting the Laplace transform. This form of solution has the advantage of applying to any visco-elastic model, and of requiring little additional computation as a result of changing the visco-elastic model, the relative raft-soil stiffness or the load pattern.The application of the method is illustrated by results for circular rafts, strip footings of finite length and rectangular rafts, and particular attention is paid to a realistic soil creep function which is asymptotic to a linear function of log time.
    Zusätzliches Material: 11 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/nag.1610030107
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