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  • 1
    Electronic Resource
    Electronic Resource
    Mechanisms of postural ataxia after intake of alcohol (1983)
    Springer
    International journal of legal medicine 90 (1983), S. 159-165 
    Details
    ISSN: 1437-1596
    Keywords: Alcohol, effect on the spinocerebellum ; Posturography ; Alkohol, Wirkung auf Spinocerebellum ; Posturographie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Law
    Description / Table of Contents: Zusammenfassung Die Alkoholwirkung auf die Standsicherheit wurde in einem Akutexperiment bei 12 gesunden Versuchspersonen untersucht. Sie tranken innerhalb 1h 11 Wein. Die danach gemessenen Blutalkoholspiegel lagen zwischen 0,9 und 1,67 mg/ml. Die Standmessung am Ende der Trinkphase und 1h danach ergab bei geschlossenen Augen eine signifikante Zunahme der Körperunruhe, vor allem durch vermehrtes antero-posteriores Schwanken. Der Vergleich der Ergebnisse der Posturographie im Akut-experiment und bei Patienten mit umschriebenen cerebellären Läsionen verschiedener Lokalisation zeigt, daß auch im Akutexperiment, wie durch den chronischen Abusus, vor allem das Spinocerebellum durch den Alkohol in seiner Funktion beeinträchtigt wird.
    Notes: Summary The effect of an acute intoxication with alcohol on the stability of stance was examined in 12 healthy subjects. They drank 11 of wine within 1h. The resulting blood alcohol concentrations ranged between 0.9 and 1.67 mg/ml. Static posturography at the end of drinking and 1h later revealed a significant increase in body sway which was mainly due to an increase in anteroposterior sway only present with closed eyes. A comparison of the results of posturography after acute intoxication with the data of patients with permanent lesions confined to the different functional subunits of the cerebellum shows that the acute effect of alcohol largely resembles that of a chronic lesion of the cerebellar anterior lobe (the spinocerebellum).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02116226
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Improvement of ataxia in alcoholic cerebellar atrophy through alcohol abstinence (1984)
    Springer
    Journal of neurology 231 (1984), S. 258-262 
    Details
    ISSN: 1432-1459
    Keywords: Alcoholic atrophy ; Alcohol abstinence ; Posturography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Postural instability was measured and short, medium and long latency EMG responses to angular displacement of the ankle were recorded from leg muscles in a group of 17 alcoholics who presented with clinical signs of cerebellar atrophy of the anterior lobe. Recordings were performed twice (average interval 18.5 months) to determine the effects of continued drinking versus abstinence on the signs of the cerebellar damage. Patients who were abstinent (n=11) exhibited a significant, sometimes dramatic decrease of body sway whereas patients who continued drinking (n=6) showed increased body sway when the eyes were closed. Short and medium latency EMG responses were unaltered in both groups of patients. The integral of the long latency response of the antagonist tended to increase with continued abuse and to decrease in abstinent patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00313662
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Antimigraine drugs (1999)
    Springer
    Journal of neurology 246 (1999), S. 515-519 
    Details
    ISSN: 1432-1459
    Keywords: Key words Migraine attack ; 5-HT1B/1D agonists ; Analgesics ; Ergotamine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Migraine is a paroxysmal disorder characterized by attacks of headache, nausea, vomiting, photophobia, phonophobia, and malaise. This review summarizes new treatment options for therapy of the acute attack. Mild or moderate migraine attacks are treated with antiemetics followed by analgesics such as aspirin, paracetamol, nonsteroidal anti-inflammatory drugs, or antiemetics combined with ergotamine or dihydroergotamine. Sumatriptan, a specific serotonin (5-HT)1B/D agonist is used when attacks do not respond to ergotamine, or when intolerable side effects occur. The new migraine drugs zolmitriptan, naratriptan, rizatriptan, and eletriptan differ slightly in their pharmacological profiles, which translates into minor differences in efficacy, headache recurrence, and side effects. New drugs in migraine prophylaxis include cyclandelate, valproic acid and magnesium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050396
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Incidence of peripheral neuropathy and cerebellar ataxia in chronic alcoholics (1986)
    Springer
    Journal of neurology 233 (1986), S. 212-217 
    Details
    ISSN: 1432-1459
    Keywords: Alcoholic neuropathy ; Alcoholic cerebellar degeneration ; Posturography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A total of 78 chronic alcoholics were examined neurologically as well as by electroneurography, myography and posturography. Clinical signs of peripheral neuropathy were detected in 45% of these patients, with electromyographic and neurographic abnormality in 67% and 55% respectively. Clinical signs of cerebellar ataxia were found in 33% of our patients, whereas posturographic measurements of increased sway were recorded in 69%. The posturographic characteristics of cerebellar anterior lobe atrophy were observed in two-thirds of the latter patients. The severity of cerebellar-ataxia did not correlate with the degree of neuropathy. This lack of correlation is interpreted as an indication of different pathogenetic mechanisms acting on peripheral nerves and cerebellum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314021
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  • 5
    Electronic Resource
    Electronic Resource
    Cerebellar dysfunction in patients with bronchogenic carcinoma: clinical and posturographic findings (1988)
    Springer
    Journal of neurology 235 (1988), S. 290-296 
    Details
    ISSN: 1432-1459
    Keywords: Posturography ; Paraneoplastic cerebellar degeneration ; Cortical cerebellar atrophy ; Bronchogenic carcinoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Neurological examination and posturography showed cerebellar signs in 13 of 50 unselected patients with bronchogenic carcinoma not complicated by other diseases. The occurrence of cerebellar signs did not depend on the histological type of tumour or the extent of tumour spread. Most of the clinically affected patients had mild to pronounced cerebellar atrophy, revealed by CT. The correlation between the amount of CT-confirmed atrophy and the severity of clinical symptoms, however, was poor. Since other reasons for cerebellar dysfunction (e.g. chemotherapy, chronic alcoholism, metastases) were excluded, cerebellar signs were attributed to paraneoplastic cerebellar degeneration or to a consequence of severe neoplastic illness. The high incidence of cerebellar dysfunction in patients with bronchogenic carcinoma confirms the frequent histopathological finding of cortical cerebellar degeneration in malignant disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00314176
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Ergotamine, flunarizine and sumatriptan do not change cerebral blood flow velocity in normal subjects and migraneurs (1991)
    Springer
    Journal of neurology 238 (1991), S. 245-250 
    Details
    ISSN: 1432-1459
    Keywords: Migraine ; Cerebral blood flow velocity ; Ergotamine ; Flunarizine ; Sumatriptan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Changes in the diameter of extracranial and intracranial arteries resulting in changes in cerebral blood flow have previously been assumed to be the most important pathophysiological factor in migraine. To test this hypothesis 20 normal subjects, and three groups of patients (n=29) with migraine were investigated by means of transcranial Doppler sonography. Blood flow velocities in the middle cerebral (MCA) and in basilar (BA) arteries were measured. Data from patients were obtained in the interval between migraine attacks, during migraine attacks and following treatment with either ergotamine (0.5 mg i.m.; n=10); flunarizine, a calcium overload blocker (20 mg i.v.; n=13); or a 5-HT1-like agonist (sumatriptan, 4 mg s.c.; n=6). Ergotamine and sumatriptan are constrictors of cerebral arteries in animal experiments. The arithemtic mean of flow velocity in the BA was reduced in normal subjects (45 cm/s) as compared with patients with migraine measured in between attacks (53 cm/s). Mean flow velocity in MCA was not different in normals (72.5 cm/s) as compared with migraineurs (75 cm/s). Neither ergotamine nor the 5-HT1 agonist and flunarizine resulted in a significant change in blood flow velocity in MCA and BA. This was true irrespective of whether the drugs were given in the headache-free period, during a migraine attack or during the withdrawal phase of drug-induced headache. Ergotamine was effective in improving headache during migraine attacks and sumatriptan attenuated headache during drug withdrawal from chronic analgesic intake. These results indicate that the action of ergotamine and the 5-HT1-receptor agonist is probably not mediated by their vasoconstrictor action on cerebral arteries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00319734
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