ISSN:
1433-8580
Keywords:
Oral antidiabetic drugs
;
Extrapancreatic action
;
Cultured fibroblasts
;
Insulin receptor
;
RNA synthesis
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We describe insulin binding and insulin-mediated RNA synthesis on seven human fibroblasts strains in culture initiated from skin biopsies in the presence of three oral antidiabetic agents, Metformin, Gliquidone, and a non-sulfonylurea antidiabetic drug (B × DF 591 ZW), which belong to different chemical classes. At least at a nontoxic pharmacologic concentration of 1 µg/ml these drugs did not influence the number and affinity of insulin receptors, nor did they increase the insulin-mediated RNA synthesis. We conclude that cultured fibroblasts do not represent the proper target for an evaluation of an extrapancreatic action of oral antidiabetic drugs.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01851526
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