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  • 1,25 Dihydroxycholecalciferol  (1)
  • ATP  (1)
  • Ferritin  (1)
  • 1
    Electronic Resource
    Electronic Resource
    The effect of 1α, 25-dihydroxycholecalciferol on iron metabolism (1985)
    Springer
    Annals of hematology 51 (1985), S. 103-108 
    Details
    ISSN: 1432-0584
    Keywords: 1α, 25-dihydroxycholecalciferol ; iron ; Calcium ; Intestinal absorption ; Ferritin ; Iron overload
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Chronic administration of hypercalcemic doses of 1α, 25-dihydroxycholecalciferol to intact, vitamin-D repleted rats for 4 weeks, enhanced net inestinal absorption of iron and liver iron stores. Daily net iron and calcium absorptions were found to be significantly correlated in both control and treated rats. In duodenal loop experiments, pretreatment with 1α, 25-dihydroxycholecalciferol reversed the adverse effect of high Ca/Fe ratio on iron absorption. The increased intestinal absorption of iron did not result in a change of serum iron levels nor of total iron binding capacity due to the enhanced incorporation of absorbed iron into liver ferritin. The curve of uptake of 59Fe into circulating red cells of treated rats suggested retarded release of the isotope from stores. The hypothesis is advanced that the systemic metabolic defect (tissue hypoxia, raised erythropoietin levels) produced by 1α, 25-dihydroxycholecalciferol is responsible for the disruption of the physiological coordination between iron stores and intestinal absorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00320118
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effects ofSolanum malacoxylon on embryonic bonein vitro and on isolated mitochondria (1974)
    Springer
    Calcified tissue international 16 (1974), S. 219-226 
    Details
    ISSN: 1432-0827
    Keywords: Bone ; Phosphate ; ATP ; Calcium ; Mitochondria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract An active constituent of the leaves ofSolanum malacoxylon (SM) is shown to promote calcium resorption and citrate production in embryonic chick frontal bone culturedin vitro. When injected into rats, SM reduces the ATP content of liver and kidneys. This phenomenon may be related to the ability of SM to stimulate mitochondrial ATPase activity at pH 9.4. SM significantly reduces the concentration of phosphate necessary to alter the uptake of calcium and respiration of siolated mitochondria. The data suggest that SM influences calcium and phosphate metabolism by affecting ion movements into and out of mitochondria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02008229
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Respiratory alkalosis and reduced plasmatic concentration of ionized calcium in rats treated with 1,25 dihydroxycholecalciferol (1984)
    Springer
    Calcified tissue international 36 (1984), S. 604-607 
    Details
    ISSN: 1432-0827
    Keywords: Respiratory alkalosis ; Ionized calcium ; 1,25 Dihydroxycholecalciferol ; Parathyroid hormone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary The daily administration of supraphysiological doses of 1,25 dihydroxycholecalciferol (0.1–2.5 µg/d/100 g body weight) to rats, produced respiratory alkalosis. With the doses of 0.1–0.2 µg/d/100 g and feeding a diet with 0.7% of calcium, calcemias did not exceed 2.75 mM, and significantly reduced plasma ionized calcium levels were measured. The latter phenomenon was found associated with increased urinary excretion of cAMP, soft tissue calcium content, and polyuria with hypostenuria, all known effects of parathyroid hormone. These effects were absent in thyroparathyroidectomized rats treated in the same fashion. Present results suggest that the stimulus of low levels of plasma ionized calcium overcomes the probably inhibitory effect of the steroid on parathyroid hormone secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02405374
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    Paper (German National Licenses)
    Fulltext
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