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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 13 (1991), S. 89-104 
    ISSN: 1279-8517
    Keywords: Gallbladder ; Lymphatic system ; Carcinoma ; Macroscopic anatomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé A partir de la dissection fine des lymphatiques de la vésicule effectuée sur 4 sujets adultes, trois voies de drainages ont pu être schématisées. 1) La voie cholécysto-rétro pancréatique qui peut être considérée comme la principale, comporte deux trajets, l'un descendant en spirale de la face antérieure de la voie biliaire principale vers son bord postéro-droit, et l'autre descendant directement à la face postérieure du conduit biliaire. Dans leur segment rétroportal, ces voies convergent vers un important nœud lymphatique qui apparaît comme le principal nœud terminal de cette voie. Nous l'avons dénommé le nœud principal rétroportal. 2) La voie cholécysto-cœliaque est utilisée par quelques lymphatiques de la vésicule biliaire qui se dirigent vers la gauche à travers le ligament hépato-duodénal pour rejoindre les nœuds cœliaques. 3) La voie cholécysto-mésentérique est empruntée par des lymphatiques qui descendent vers la gauche en avant de la veine porte et rejoignant les nœuds situés à l'origine de l'artère mésentérique supérieure. Ces trois voies convergent vers les nœuds lymphatiques abdomino-aortiques situés à proximité de la veine rénale gauche; les nœuds situés dans l'espace inter-aortico-cave seront particulièrement importants.
    Notes: Summary Based upon the detailed dissections of the lymphatic system of four adult cadavers, the lymphatic drainage of the gallbladder was divided into three pathways. 1) The cholecysto-retropancreatic pathway, which can be regarded as the main pathway, had two routes, one running spirally and posteriorly from the anterior surface of the common bile duct to the right, and the other running almost straight down from the posterior surface of the common bile duct. At the retroportal segment, these routes converged at a large lymph node, which appeared critical as the main terminal lymph node of this pathway. We designated this node the principal retroportal node. 2) The cholecysto-celiac pathway was the route by which some of the lymphatics from the gallbladder ran to the left through the hepatoduodenal ligament to reach the celiac nodes. 3) The cholecysto-mesenteric pathway was the route by which some of the lymphatics ran to the left in front of the portal vein and connected with the nodes at the superior mesenteric root. These three pathways converged with the abdomino-aortic lymph nodes near the left renal vein; in particular, the nodes in the interaortico-caval space were considered important.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 278 (1986), S. 329-334 
    ISSN: 1432-069X
    Keywords: Melanoma metastasis ; Interferon ; Time-dependent suppression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effect of murine α/β interferon (IFN) on experimental metastasis was investigated using B16-F10 melanoma cells. Since the outcome of metastasis of blood-borne tumor cells is mainly determined within the first 24 h after i.v. inoculation of tumor cells, i.p. injection of IFN was focused on this critical early phase. The inhibition of pulmonary metastases by IFN was found to be maximal when given 3 h prior to tumor cell inoculation, while mice with 24-h and 12-h pretreatment and simultaneous IFN treatment also showed a reduction in metastases, but to a lesser extent. However, mice receiving IFN 2 h after tumor cell inoculation did not show any reduction. Tumor cells cultured for 24 h in IFN-containing medium showed no reduction in metastases. Administration of anti-asialo GMl prior to IFN treatment was found to eliminate the inhibitory effect of IFN 3 h pretreatment. However, natural killer (NK) cell activity in vitro measured at 3 h, 13 h and 24 h after IFN administration was enhanced to the same extent, not paralleling the inhibitory effect on pulmonary metastases. These data indicate that prepared host status against blood-borne tumor cells is established by IFN pretreatment, being maximal when injected several hours prior to tumor cell inoculation, and that this effect is substantially dependent on NK cell activity, though the implication of other factors is not excluded.
    Type of Medium: Electronic Resource
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